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LINGO1 and FBXW7
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
LINGO1
FBXW7
Gene Name
leucine rich repeat and Ig domain containing 1
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
SCF Ubiquitin Ligase Complex
Protein Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Epidermal Growth Factor Receptor Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Cyclin Binding
Protein Binding, Bridging
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activator Activity
Biological Process
Central Nervous System Neuron Development
Neuron Projection Development
Protein Kinase B Signaling
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Oligodendrocyte Differentiation
Regulation Of Axonogenesis
Negative Regulation Of Axonogenesis
Vasculogenesis
Vasculature Development
Regulation Of Transcription, DNA-templated
Cellular Response To DNA Damage Stimulus
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Viral Process
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of DNA Endoreduplication
Regulation Of Protein Localization
Cellular Response To UV
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Pathways
Signalling by NGF
Axonal growth inhibition (RHOA activation)
p75NTR regulates axonogenesis
p75 NTR receptor-mediated signalling
Protein folding
Antigen processing: Ubiquitination & Proteasome degradation
Chaperonin-mediated protein folding
Association of TriC/CCT with target proteins during biosynthesis
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Essential tremor (
19182806
)
Protein-Protein Interactions
8 interactors:
EFEMP2
FBXW7
GOLGA2
KRTAP4-12
NGFR
RTN4R
SPAG5
TRIM27
33 interactors:
ARL6IP1
CCNE1
CCNE2
CDC34
CREB3L1
CREB3L2
CUL1
EBNA1BP2
FAM101A
GLMN
GNB2L1
HEY1
HIPK2
JUN
KIAA1875
KLF5
LINGO1
MCL1
MED13
MED13L
MMS22L
MYB
MYC
NOTCH1
NOTCH4
PARK2
PPARGC1A
PSEN1
SHPRH
SKP1
STOML1
SUMF2
UBE2D1
Entrez ID
84894
55294
HPRD ID
14322
05888
Ensembl ID
ENSG00000169783
ENSG00000109670
Uniprot IDs
Q96FE5
B7Z2C8
G0Z2K0
Q969H0
S4R3U4
PDB IDs
2ID5
2OVP
2OVQ
2OVR
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Axonogenesis
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Cell Morphogenesis Involved In Differentiation
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Triglyceride Biosynthetic Process
Negative Regulation Of Interleukin-2 Secretion
Negative Regulation Of Cell Projection Organization
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hair Follicle Development
Regulation Of Axonogenesis
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of Hair Cycle
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Regulation Of Protein Localization
Regulation Of Organ Morphogenesis
Regulation Of Cellular Component Organization
Negative Regulation Of Neuron Differentiation
Negative Regulation Of DNA Endoreduplication
Positive Regulation Of Apoptotic Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Calcium Ion Import
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Neurotrophin Signaling Pathway
Chromosome Segregation
Positive Regulation Of Oxidative Stress-induced Cell Death
Interferon-gamma Secretion
Regulation Of DNA Endoreduplication
Negative Regulation Of Neurogenesis
Regulation Of Hepatocyte Proliferation
Positive Regulation Of Odontogenesis
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Development
Negative Regulation Of Viral Release From Host Cell
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Odontogenesis Of Dentin-containing Tooth
Regulation Of Neuron Projection Development
Membrane Protein Intracellular Domain Proteolysis
Regulation Of Hair Follicle Development
Cell Cycle
Regulation Of Triglyceride Biosynthetic Process
Interferon-gamma Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Glucose Import In Response To Insulin Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Viral Transcription
Regulation Of Hair Cycle
Regulation Of Viral Release From Host Cell
Regulation Of Calcium Ion Import
Negative Regulation Of Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Notch Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Neuron Death
Cellular Response To Stress
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Positive Regulation Of Cellular Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Protein Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
RNA Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Proteolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Response To Organic Substance
Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Response To Organic Substance
Regulation Of Protein Ubiquitination
Negative Regulation Of Neuron Death
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Regulation Of Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Cellular Response To Stimulus
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Death
Cell Cycle Phase Transition
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Gene Expression
Tagcloud
?
bcl11b
cadherin
discovered
dnm2
druggable
exhibitedthe
fat1
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Difference)
?
bcl11b
cadherin
discovered
dnm2
druggable
exhibitedthe
fat1
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Intersection)
?