MYLK and ACTC1

Number of citations of the paper that reports this interaction (PMID 12110694)
12

Data Source:
HPRD (in vivo, in vitro)

		MYLK	ACTC1
Gene Name		myosin light chain kinase	actin, alpha, cardiac muscle 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cleavage Furrow Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Calmodulin-dependent Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Actin Filament Organization Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways		Smooth Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		13 interactors: ACTA1 ACTC1 CALM1 CAMK2G CTTN GOPC MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC	35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1
Entrez ID		4638	70
HPRD ID		02952	00015
Ensembl ID		ENSG00000065534	ENSG00000159251
Uniprot IDs		B4DUE3 Q15746 Q6P2N0	B3KPP5 P68032
PDB IDs		2CQV 2K0F 2YR3
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Innate Immune Response Fc Receptor Signaling Pathway Wound Healing Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Response To Abiotic Stimulus Actin Filament-based Process Actin-myosin Filament Sliding Muscle Filament Sliding Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Response To Wounding Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cellular Component Assembly Epidermal Growth Factor Receptor Signaling Pathway Anatomical Structure Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Actin-mediated Cell Contraction Immune Response Regulation Of Kinase Activity Protein Phosphorylation Blood Coagulation Hemostasis Defense Response Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Peptidyl-serine Autophosphorylation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Muscle Contraction	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?