MYLK and CAMK2G

Number of citations of the paper that reports this interaction (PubMedID 2160950)
0

Data Source:
HPRD (in vivo, in vitro)

		MYLK	CAMK2G
Description		myosin light chain kinase	calcium/calmodulin dependent protein kinase II gamma
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow Cell Projection Synapse	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Scaffold Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Smooth Muscle Contraction Muscle Organ Development Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing Regulation Of Synaptic Vesicle Endocytosis	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane
Pathways		Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Ritodrine Fostamatinib	Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		General cognitive ability ( 29844566)	Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC	51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		4638	818
HPRD ID		02952	03672
Ensembl ID		ENSG00000065534	ENSG00000148660
Uniprot IDs		A0A8I5KTQ1 A0A8I5KU53 Q05B97 Q05B98 Q15746	A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3
PDB IDs		2CQV 2K0F 2YR3 5JQA 5JTH 6C6M	2UX0 2V7O
Enriched GO Terms of Interacting Partners?		Actin Filament Focal Adhesion Protein Kinase Activity ATP Binding Cytoskeleton Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Muscle System Process Nucleotide Binding Intracellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of System Process Mesenchyme Migration Positive Regulation Of Locomotion Caveolin-mediated Endocytosis Protein Phosphorylation Skeletal Muscle Thin Filament Assembly Sarcomere Cytosol Phosphorylation Lamellipodium Regulation Of Transport Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Caveola Cytoplasm Identical Protein Binding Negative Regulation Of Apoptotic Process Regulation Of Monoatomic Anion Transport Regulation Of Cellular Localization Cellular Response To Nutrient Levels Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Protein Localization Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport Response To Growth Factor Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Locomotion Regulation Of MAPK Cascade ERBB2 Signaling Pathway	Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration
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