MYLK and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYLK	APPBP2
Description		myosin light chain kinase	amyloid beta precursor protein binding protein 2
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow Cell Projection Synapse	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Scaffold Protein Binding	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Phosphorylation Smooth Muscle Contraction Muscle Organ Development Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing Regulation Of Synaptic Vesicle Endocytosis	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways		Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Ritodrine Fostamatinib
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		General cognitive ability ( 29844566)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		4638	10513
HPRD ID		02952	05616
Ensembl ID		ENSG00000065534	ENSG00000062725
Uniprot IDs		A0A8I5KTQ1 A0A8I5KU53 Q05B97 Q05B98 Q15746	Q92624
PDB IDs		2CQV 2K0F 2YR3 5JQA 5JTH 6C6M	8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Actin Filament Focal Adhesion Protein Kinase Activity ATP Binding Cytoskeleton Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Muscle System Process Nucleotide Binding Intracellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of System Process Mesenchyme Migration Positive Regulation Of Locomotion Caveolin-mediated Endocytosis Protein Phosphorylation Skeletal Muscle Thin Filament Assembly Sarcomere Cytosol Phosphorylation Lamellipodium Regulation Of Transport Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Caveola Cytoplasm Identical Protein Binding Negative Regulation Of Apoptotic Process Regulation Of Monoatomic Anion Transport Regulation Of Cellular Localization Cellular Response To Nutrient Levels Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Protein Localization Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport Response To Growth Factor Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Locomotion Regulation Of MAPK Cascade ERBB2 Signaling Pathway	Protein Binding
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