MYLK and GOPC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYLK	GOPC
Description		myosin light chain kinase	golgi associated PDZ and coiled-coil motif containing
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow Cell Projection Synapse	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex Cell Projection Synapse
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Scaffold Protein Binding	Protein Binding Identical Protein Binding Transmembrane Transporter Binding Molecular Sequestering Activity
	Biological Process	Protein Phosphorylation Smooth Muscle Contraction Muscle Organ Development Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing Regulation Of Synaptic Vesicle Endocytosis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface
Pathways		Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs	RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs		Ritodrine Fostamatinib
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		General cognitive ability ( 29844566)	Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Mild obesity-related type 2 diabetes ( 34737425) Night sleep phenotypes ( 27126917)
Interacting Genes		15 interacting genes: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC	71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CEBPA CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 UBE3A VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1
Entrez ID		4638	57120
HPRD ID		02952	06024
Ensembl ID		ENSG00000065534	ENSG00000047932
Uniprot IDs		A0A8I5KTQ1 A0A8I5KU53 Q05B97 Q05B98 Q15746	Q9HD26
PDB IDs		2CQV 2K0F 2YR3 5JQA 5JTH 6C6M	2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ 7JZO 7JZP 7JZQ 7JZR
Enriched GO Terms of Interacting Partners?		Actin Filament Focal Adhesion Protein Kinase Activity ATP Binding Cytoskeleton Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Muscle System Process Nucleotide Binding Intracellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of System Process Mesenchyme Migration Positive Regulation Of Locomotion Caveolin-mediated Endocytosis Protein Phosphorylation Skeletal Muscle Thin Filament Assembly Sarcomere Cytosol Phosphorylation Lamellipodium Regulation Of Transport Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Caveola Cytoplasm Identical Protein Binding Negative Regulation Of Apoptotic Process Regulation Of Monoatomic Anion Transport Regulation Of Cellular Localization Cellular Response To Nutrient Levels Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Protein Localization Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport Response To Growth Factor Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Locomotion Regulation Of MAPK Cascade ERBB2 Signaling Pathway	Response To Lipid Phagocytic Vesicle PDZ Domain Binding Golgi-associated Vesicle Membrane Response To Xenobiotic Stimulus Positive Regulation Of Cellular Component Biogenesis Phagocytosis, Engulfment Response To Vitamin Negative Regulation Of Cell Population Proliferation Regeneration Liver Development Response To Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Positive Regulation Of Reactive Oxygen Species Metabolic Process Glutamatergic Synapse Transcription Factor AP-1 Complex Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Scaffold Protein Binding SMAD Protein Signal Transduction Postsynapse To Nucleus Signaling Pathway Response To Muramyl Dipeptide Membrane Hyperpolarization Negative Regulation Of Skeletal Muscle Cell Differentiation Myeloid Leukocyte Differentiation Hormone-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Stem Cell Proliferation Signal Transduction Organic Hydroxy Compound Transport Integrated Stress Response Signaling Synaptic Signaling Via Neuropeptide Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production
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