MYLK

Name	myosin light chain kinase
Structure
Interactors	15 interactors: ACTA1 ACTC1 APPBP2 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow Cell Projection Synapse
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Protein Phosphorylation Smooth Muscle Contraction Muscle Organ Development Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing Regulation Of Synaptic Vesicle Endocytosis
Pathways	Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs	Ritodrine Fostamatinib
Diseases	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS	General cognitive ability ( 29844566 )
Entrez ID	4638
HPRD ID	02952
Ensembl ID	ENSG00000065534
Uniprot IDs	A0A8I5KTQ1 A0A8I5KU53 Q05B97 Q05B98 Q15746
PDB IDs	2CQV 2K0F 2YR3 5JQA 5JTH 6C6M
GO Terms Enriched among Interactors ?	Actin Filament Focal Adhesion Protein Kinase Activity ATP Binding Cytoskeleton Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Muscle System Process Nucleotide Binding Intracellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of System Process Mesenchyme Migration Positive Regulation Of Locomotion Caveolin-mediated Endocytosis Protein Phosphorylation Skeletal Muscle Thin Filament Assembly Sarcomere Cytosol Phosphorylation Lamellipodium Regulation Of Transport Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Caveola Cytoplasm Identical Protein Binding Negative Regulation Of Apoptotic Process Regulation Of Monoatomic Anion Transport Regulation Of Cellular Localization Cellular Response To Nutrient Levels Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Protein Localization Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport Response To Growth Factor Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Locomotion Regulation Of MAPK Cascade ERBB2 Signaling Pathway