MYL6 and MLH1

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MYL6	MLH1
Gene Name		myosin, light chain 6, alkali, smooth muscle and non-muscle	mutL homolog 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Myosin Complex Unconventional Myosin Complex Vesicle Extracellular Vesicular Exosome	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex
	Molecular Function	Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Actin-dependent ATPase Activity	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Muscle Contraction Axon Guidance Skeletal Muscle Tissue Development Metabolic Process Muscle Filament Sliding Ephrin Receptor Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions Smooth Muscle Contraction EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ADAMTS12 DNAJB9 EWSR1 GLP1R MLH1 MOB4 NUDT21	74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1
Entrez ID		4637	4292
HPRD ID		17618	00390
Ensembl ID		ENSG00000092841	ENSG00000076242
Uniprot IDs		B7Z6Z4 F8VZU9 G3V1Y7 P60660 Q6IBG5	P40692 Q59EG3
PDB IDs			3NA3 3RBN
Enriched GO Terms of Interacting Partners?		MRNA 3'-end Processing Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus Meiotic Spindle Midzone Assembly Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Meiotic Metaphase I Plate Congression RNA 3'-end Processing Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Mitotic Recombination Proteoglycan Catabolic Process Regulation Of Mitotic Recombination Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Male Meiosis Chromosome Segregation Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Spindle Midzone Assembly	Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction
Tagcloud ?			9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?			9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?