FAM124B and SP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM124B	SP7
Description		family with sequence similarity 124 member B	Sp7 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Chromatin Nucleus Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Metal Ion Binding
	Biological Process		Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Gene Expression Response To Insulin Cellular Response To Zinc Ion Starvation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Diphosphate Metabolic Process Cementum Mineralization Positive Regulation Of Stem Cell Differentiation
Pathways			RUNX2 regulates osteoblast differentiation
Drugs
Diseases
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Familial squamous cell lung carcinoma ( 29924316)	Apolipoprotein A1 levels ( 32203549) Bone mineral density (spine) ( 19079262 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias (moderate to severe) ( 31856834) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		67 interacting genes: ABI1 ABI3 ADAMTSL4 BIRC7 BLZF1 CARD9 CCDC85B CYSRT1 DRC12 EFEMP2 EFHC2 ESM1 GIGYF1 GKAP1 GOLGA2 GPRASP2 GPRASP3 GRB7 HSF2BP IHO1 IKZF3 ISCA2 KCTD6 KCTD9 KIAA1958 KRT19 KRT31 KRT40 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP9-3 LHX3 LZTS2 MBD3L1 MDFI MIPOL1 MKRN3 MTUS2 MYF5 NADK NOTCH2NLA RBPMS RINT1 RSPH3 SEPTIN14 SH2B2 SP7 SSX2IP TCF4 TLE5 TRAF2 TRIM37 TRIM42 TRIM54 TRIM8 TRIM9 TRIP6 USHBP1 USP54 WDR83 ZBED1 ZNF69 ZNF774 ZRANB1	11 interacting genes: CBL CBLB DRC4 FAM124B FBXW7 HNF1B MAPK14 NFIC NFIX QARS1 TRIM62
Entrez ID		79843	121340
HPRD ID		08663	05971
Ensembl ID		ENSG00000124019	ENSG00000170374
Uniprot IDs		Q9H5Z6	Q8TDD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Keratin Filament Intermediate Filament Protein Binding Ubiquitin Protein Ligase Activity Signaling Adaptor Activity Post-translational Protein Modification Cytoskeleton Protein Modification By Small Protein Conjugation Protein Ubiquitination	Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-protein Transferase Activity Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Receptor Tyrosine Kinase Binding Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Animal Organ Development Regulation Protein Catabolic Process At Postsynapse Cellular Response To UV Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Synaptic Membrane Adhesion Cis-regulatory Region Sequence-specific DNA Binding Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Regulation Of Pronephros Size Positive Regulation Of Antifungal Innate Immune Response Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Negative Regulation Of Cell Communication
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