APEX2 and TSHZ3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APEX2	TSHZ3
Description		apurinic/apyrimidinic endodeoxyribonuclease 2	teashirt zinc finger homeobox 3
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion	Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone Cell Projection
	Molecular Function	DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity Hydrolase Activity Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	DNA Repair Base-excision Repair DNA Recombination DNA Damage Response	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation
Pathways
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive performance ( 19734545) Corneal astigmatism ( 30306274) Diastolic blood pressure ( 27841878) Falling risk ( 32999390) FEV1 ( 30804560) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Lung function (FEV1/FVC) ( 30061609 30804560) Peak expiratory flow ( 30804560) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Post bronchodilator FEV1 in COPD ( 26634245) Refractive error ( 32231278) Systemising ( 31508503) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		18 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3 UBC	30 interacting genes: ANKRA2 APBB1 APEX2 CCHCR1 CEP63 CEP70 COG6 CTBP1 CTBP2 GOLGA2 HSF2BP KASH5 KRT31 KRT40 LRRC73 MAD1L1 MRPL28 MTUS2 PIBF1 RINT1 ROPN1 SPAG5 TAX1BP1 TEPSIN TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSC1
Entrez ID		27301	57616
HPRD ID		06442	18351
Ensembl ID		ENSG00000169188	ENSG00000121297
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q63HK5
PDB IDs			2DMI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Golgi-associated Vesicle Enzyme Binding Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Identical Protein Binding Protein Modification Process Syntaxin-1 Binding Ubiquitin Protein Ligase Binding MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Growth Cone Endocytosis Negative Regulation Of Macromolecule Metabolic Process Protein Homodimerization Activity Positive Regulation Of Autophagy DAPK1-calmodulin Complex Cytoskeleton Positive Regulation Of Autophagic Cell Death Ubiquitin Protein Ligase Activity Tumor Necrosis Factor Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination PCNA Complex Replisome TORC2 Complex Disassembly Neuromuscular Junction Development Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential	Spindle Organization Spindle Assembly Cytoskeleton Cytoplasm Identical Protein Binding Spindle Pole Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Metaphase Plate Congression DNA Damage Response White Fat Cell Differentiation Microtubule-based Process Viral Genome Replication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?