APEX2 and NINL

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		APEX2	NINL
Gene Name		APEX nuclease (apurinic/apyrimidinic endonuclease) 2	ninein-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Mitochondrial Inner Membrane Intracellular Membrane-bounded Organelle	Microtubule Organizing Center Cytosol Microtubule
	Molecular Function	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity	Calcium Ion Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Base-excision Repair DNA Recombination Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APP CALCOCO2 CCDC85B EFEMP2 HOOK2 NEDD4L NINL PCNA PGR TRAF2 TRIM37	45 interactors: AKAP17A APEX2 CCDC130 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 RBM41 RCOR3 RGS2 RIBC2 SH2D4A SH3BP5L SPERT SYT17 TCEANC TCEB3 TNNT1 TSPYL4 UTP14A ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		27301	22981
HPRD ID		06442	11120
Ensembl ID			ENSG00000101004
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q9Y2I6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Monoubiquitination Protein Autoubiquitination Positive Regulation Of Deoxyribonuclease Activity Regulation Of Transcription From RNA Polymerase II Promoter Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Histone H2A-K119 Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cell Maturation Response To Stress Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Gene Expression Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Nitrogen Compound Metabolic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glial Cell Apoptotic Process Cellular Homeostasis Response To Organic Substance Intracellular Receptor Signaling Pathway Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Mammary Gland Branching Involved In Pregnancy DNA-templated Transcription, Initiation Negative Regulation Of Sodium Ion Transport Translesion Synthesis	RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Gene Expression Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Peptidyl-lysine Modification Protein Acetylation Cellular Nitrogen Compound Metabolic Process Chromatin Organization Protein Localization To Chromatin Chromosome Organization Cell Cycle Histone H4-K5 Acetylation Histone H4-K8 Acetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Contraction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Organelle Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Protein Localization To Chromosome Cell Cycle Process Mitotic Spindle Checkpoint Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Segregation Mitotic Nuclear Division Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Ubiquitin-dependent Endocytosis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast
Tagcloud (Difference) ?		applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast
Tagcloud (Intersection) ?