APEX2 and NINL

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		APEX2	NINL
Description		apurinic/apyrimidinic endodeoxyribonuclease 2	ninein like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule
	Molecular Function	DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity Hydrolase Activity Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	DNA Repair Base-excision Repair DNA Recombination DNA Damage Response	Microtubule Anchoring At Centrosome
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)
Interacting Genes		18 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3 UBC	52 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		27301	22981
HPRD ID		06442	11120
Ensembl ID		ENSG00000169188	ENSG00000101004
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q9Y2I6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Golgi-associated Vesicle Enzyme Binding Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Identical Protein Binding Protein Modification Process Syntaxin-1 Binding Ubiquitin Protein Ligase Binding MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Growth Cone Endocytosis Negative Regulation Of Macromolecule Metabolic Process Protein Homodimerization Activity Positive Regulation Of Autophagy DAPK1-calmodulin Complex Cytoskeleton Positive Regulation Of Autophagic Cell Death Ubiquitin Protein Ligase Activity Tumor Necrosis Factor Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination PCNA Complex Replisome TORC2 Complex Disassembly Neuromuscular Junction Development Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential	Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome
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