APEX2 and HOOK2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APEX2	HOOK2
Description		apurinic/apyrimidinic endodeoxyribonuclease 2	hook microtubule tethering protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex
	Molecular Function	DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity Hydrolase Activity Metal Ion Binding	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	DNA Repair Base-excision Repair DNA Recombination DNA Damage Response	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		18 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3 UBC	127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844
Entrez ID		27301	29911
HPRD ID		06442	09698
Ensembl ID		ENSG00000169188	ENSG00000095066
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q96ED9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Golgi-associated Vesicle Enzyme Binding Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Identical Protein Binding Protein Modification Process Syntaxin-1 Binding Ubiquitin Protein Ligase Binding MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Growth Cone Endocytosis Negative Regulation Of Macromolecule Metabolic Process Protein Homodimerization Activity Positive Regulation Of Autophagy DAPK1-calmodulin Complex Cytoskeleton Positive Regulation Of Autophagic Cell Death Ubiquitin Protein Ligase Activity Tumor Necrosis Factor Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination PCNA Complex Replisome TORC2 Complex Disassembly Neuromuscular Junction Development Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential	Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing
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