APEX2 and TRIM37

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		APEX2	TRIM37
Name		apurinic/apyrimidinic endodeoxyribonuclease 2	tripartite motif containing 37
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity Hydrolase Activity Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	DNA Repair Base-excision Repair DNA Recombination DNA Damage Response	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly
Pathways		None	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		No GWAS studies recorded	Cognitive function ( 25644384 ) General cognitive ability ( 29844566 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Testicular germ cell tumor ( 23666239 )
Interacting Genes		18 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3 UBC	76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655
Entrez ID		27301	4591
HPRD ID		06442	05463
Ensembl ID		ENSG00000169188	ENSG00000108395
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	O94972
PDB IDs		Not available	3LRQ
GO Terms Enriched among Interactors		Positive Regulation Of Catabolic Process Golgi-associated Vesicle Enzyme Binding Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Identical Protein Binding Protein Modification Process Syntaxin-1 Binding Ubiquitin Protein Ligase Binding MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Growth Cone Endocytosis Negative Regulation Of Macromolecule Metabolic Process Protein Homodimerization Activity Positive Regulation Of Autophagy DAPK1-calmodulin Complex Cytoskeleton Positive Regulation Of Autophagic Cell Death Ubiquitin Protein Ligase Activity Tumor Necrosis Factor Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination PCNA Complex Replisome TORC2 Complex Disassembly Neuromuscular Junction Development Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential	Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination