APEX2 and CALCOCO2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		APEX2	CALCOCO2
Gene Name		APEX nuclease (apurinic/apyrimidinic endonuclease) 2	calcium binding and coiled-coil domain 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Mitochondrial Inner Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Base-excision Repair DNA Recombination Cell Cycle	Viral Process Response To Interferon-gamma
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APP CALCOCO2 CCDC85B EFEMP2 HOOK2 NEDD4L NINL PCNA PGR TRAF2 TRIM37	143 interactors: ABLIM1 ADSL AES AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 BAHD1 BCL6B BEX2 C20orf195 CBX8 CCDC185 CCDC33 CCNH CEP57L1 CHCHD3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FXR2 GABARAPL1 GABARAPL2 GATAD2B GEMIN4 GIT2 GLYCTK HDAC7 HOXB9 IKBKG KANSL1 KAT7 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAVS MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYO6 NAA10 NDN NFU1 ORC5 PAPD4 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI PPP1R18 PRKAB2 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 SDCBP SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STK16 TAX1BP1 TBC1D22B TBK1 TBRG4 TCEB3B TCL1A TEKT3 TP53RK TRAF2 TRAF4 TRAF6 UBAC2 UBB UBC VARS VPS72 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638
Entrez ID		27301	10241
HPRD ID		06442	06846
Ensembl ID			ENSG00000136436
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q13137
PDB IDs			3VVV 3VVW 4GXL 4HAN
Enriched GO Terms of Interacting Partners?		Protein Monoubiquitination Protein Autoubiquitination Positive Regulation Of Deoxyribonuclease Activity Regulation Of Transcription From RNA Polymerase II Promoter Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Histone H2A-K119 Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cell Maturation Response To Stress Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Gene Expression Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Nitrogen Compound Metabolic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glial Cell Apoptotic Process Cellular Homeostasis Response To Organic Substance Intracellular Receptor Signaling Pathway Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Mammary Gland Branching Involved In Pregnancy DNA-templated Transcription, Initiation Negative Regulation Of Sodium Ion Transport Translesion Synthesis	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production MRNA Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter JNK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Modification By Small Protein Conjugation Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Type I Interferon Production Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity G1/S Transition Of Mitotic Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast	ad astrocytes atg atgs autophagic autophagy avs beneficial brains clear clearance enhancement expected facilitating flux hippocampal impairment lc3 localized microglia mouse ndp52 p62 phosphorylated plaques reflecting sqstm1 tau vesicles
Tagcloud (Difference) ?		applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast	ad astrocytes atg atgs autophagic autophagy avs beneficial brains clear clearance enhancement expected facilitating flux hippocampal impairment lc3 localized microglia mouse ndp52 p62 phosphorylated plaques reflecting sqstm1 tau vesicles
Tagcloud (Intersection) ?