MSH4 and MLH1

Number of citations of the paper that reports this interaction (PMID 10928988)
38

Data Source:
HPRD (in vitro, in vivo)

		MSH4	MLH1
Gene Name		mutS homolog 4	mutL homolog 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Nucleus Mismatch Repair Complex	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Meiotic Mismatch Repair Ovarian Follicle Development Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Homologous Chromosome Segregation Chiasma Assembly	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly
Pathways		Meiotic recombination	Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MLH1 MLH3 MSH5 RPA1 VBP1	74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1
Entrez ID		4438	4292
HPRD ID		03658	00390
Ensembl ID		ENSG00000057468	ENSG00000076242
Uniprot IDs		O15457	P40692 Q59EG3
PDB IDs			3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Mismatch Repair Meiotic Nuclear Division Meiotic Cell Cycle Reciprocal Meiotic Recombination DNA Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Meiosis I DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Segregation Chromosome Organization Reproduction Cell Cycle Process DNA Metabolic Process Cell Cycle Male Meiosis Cellular Response To Stress Cellular Component Assembly Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Double-strand Break Repair Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation DNA Recombinase Assembly Organelle Organization Chiasma Assembly Spindle Midzone Assembly Response To Stress Female Meiosis I Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Synaptonemal Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Synaptonemal Complex Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Nucleobase-containing Compound Metabolic Process Mitotic Recombination	Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction
Tagcloud ?		2480delg 2480t 286c anaplastic astrocytomas codon contributed exceptionally exome fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense mutational neurofibroma nf2 r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?		2480delg 2480t 286c anaplastic astrocytomas codon contributed exceptionally exome fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense mutational neurofibroma nf2 r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?