MSH4 and RPA1

Number of citations of the paper that reports this interaction (PMID 11950880)
98

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		MSH4	RPA1
Gene Name		mutS homolog 4	replication protein A1, 70kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Nucleus Mismatch Repair Complex	Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding	Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Meiotic Mismatch Repair Ovarian Follicle Development Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Homologous Chromosome Segregation Chiasma Assembly	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly In Utero Embryonic Development DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair DNA Recombination Meiotic Nuclear Division Positive Regulation Of Cell Proliferation Hemopoiesis Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cellular Response To Heat
Pathways		Meiotic recombination	HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MLH1 MLH3 MSH5 RPA1 VBP1	63 interactors: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM ATRIP BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CDK1 CDK2 CPE CSNK2B DMC1 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HUS1 MCM2 MCM4 MCM6 MCM7 MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC
Entrez ID		4438	6117
HPRD ID		03658	01565
Ensembl ID		ENSG00000057468	ENSG00000132383
Uniprot IDs		O15457	P27694
PDB IDs			1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH
Enriched GO Terms of Interacting Partners?		Mismatch Repair Meiotic Nuclear Division Meiotic Cell Cycle Reciprocal Meiotic Recombination DNA Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Meiosis I DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Segregation Chromosome Organization Reproduction Cell Cycle Process DNA Metabolic Process Cell Cycle Male Meiosis Cellular Response To Stress Cellular Component Assembly Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Double-strand Break Repair Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation DNA Recombinase Assembly Organelle Organization Chiasma Assembly Spindle Midzone Assembly Response To Stress Female Meiosis I Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Synaptonemal Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Synaptonemal Complex Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Nucleobase-containing Compound Metabolic Process Mitotic Recombination	DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Regulation Of Cell Cycle Response To Ionizing Radiation DNA Conformation Change Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Organelle Organization DNA Catabolic Process Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Response To Radiation Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cell Cycle Phase Transition DNA Strand Elongation Involved In DNA Replication Cellular Response To Stimulus Response To Abiotic Stimulus DNA Strand Elongation Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Cellular Macromolecule Biosynthetic Process
Tagcloud ?		2480delg 2480t 286c anaplastic astrocytomas codon contributed exceptionally exome fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense mutational neurofibroma nf2 r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53	200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1
Tagcloud (Difference) ?		2480delg 2480t 286c anaplastic astrocytomas codon contributed exceptionally exome fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense mutational neurofibroma nf2 r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53	200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1
Tagcloud (Intersection) ?