MME and NDRG1

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		MME	NDRG1
Description		membrane metalloendopeptidase	N-myc downstream regulated 1
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Early Endosome Trans-Golgi Network Centrosome Cytosol Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Ciliary Basal Body Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Binding Protein Homodimerization Activity Metal Ion Binding Oligopeptidase Activity Cardiolipin Binding	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Learning Or Memory Substance P Catabolic Process Bradykinin Catabolic Process Protein Processing Sensory Perception Of Pain Protein Catabolic Process Lung Development Hormone Catabolic Process Response To Estrogen Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia
Pathways		Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		20 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 SNCA TMEM132D VIP	71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		4311	10397
HPRD ID		00392	05586
Ensembl ID		ENSG00000196549	ENSG00000104419
Uniprot IDs		P08473 Q3KQS6	Q8N959 Q92597
PDB IDs		1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP	6ZMM
Enriched GO Terms of Interacting Partners?		Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Biological Quality Positive Regulation Of Heart Contraction Intracellular Signal Transduction Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Metabolic Process Signaling Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Vascular Process In Circulatory System Extracellular Region Positive Regulation Of Small Molecule Metabolic Process Regulation Of Vasoconstriction Signal Release Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of Blood Pressure Circulatory System Process Negative Regulation Of MAPK Cascade Regulation Of Locomotion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Transport Regulation Of Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Secretion Protein Kinase CK2 Complex	Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression
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