MME and PIK3CB

Number of citations of the paper that reports this interaction (PubMedID 12529960)
0

Data Source:
HPRD (in vitro, in vivo)

		MME	PIK3CB
Description		membrane metalloendopeptidase	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Early Endosome Trans-Golgi Network Centrosome Cytosol Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Ciliary Basal Body Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Midbody
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Binding Protein Homodimerization Activity Metal Ion Binding Oligopeptidase Activity Cardiolipin Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Protein Serine Kinase Activity
	Biological Process	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Learning Or Memory Substance P Catabolic Process Bradykinin Catabolic Process Protein Processing Sensory Perception Of Pain Protein Catabolic Process Lung Development Hormone Catabolic Process Response To Estrogen Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation	Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Leukocyte Mediated Immunity Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Endocytosis Autophagy Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Migration Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Embryonic Cleavage Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Platelet Aggregation Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Clathrin-dependent Endocytosis
Pathways		Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat	Caffeine XL765
Diseases
GWAS		Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494)
Interacting Genes		20 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 SNCA TMEM132D VIP	13 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PIK3R2 PRKCD PRKCE RAB5B YWHAQ
Entrez ID		4311	5291
HPRD ID		00392	04234
Ensembl ID		ENSG00000196549	ENSG00000051382
Uniprot IDs		P08473 Q3KQS6	B4DER4 P42338
PDB IDs		1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP
Enriched GO Terms of Interacting Partners?		Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Biological Quality Positive Regulation Of Heart Contraction Intracellular Signal Transduction Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Metabolic Process Signaling Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Vascular Process In Circulatory System Extracellular Region Positive Regulation Of Small Molecule Metabolic Process Regulation Of Vasoconstriction Signal Release Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of Blood Pressure Circulatory System Process Negative Regulation Of MAPK Cascade Regulation Of Locomotion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Transport Regulation Of Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Secretion Protein Kinase CK2 Complex	Intracellular Signaling Cassette Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Biological Quality Regulation Of Cytoskeleton Organization Exploration Behavior Regulation Of Actin Filament Polymerization Fc-gamma Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Import Into Nucleus Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Transport Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Kidney Size Cellular Response To Peptide Hormone Stimulus 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Organelle Organization Fc Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cellular Response To Oxygen-containing Compound Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Size Cellular Response To UV Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Insulin Receptor Substrate Binding Cellular Response To Insulin Stimulus Positive Regulation Of Protein Localization To Nucleus Locomotory Exploration Behavior Response To Peptide Hormone Cellular Response To Light Stimulus Protein Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?