MME and GAST

Number of citations of the paper that reports this interaction (PubMedID 2736261)
0

Data Source:
HPRD (in vitro)

		MME	GAST
Description		membrane metalloendopeptidase	gastrin
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Early Endosome Trans-Golgi Network Centrosome Cytosol Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Ciliary Basal Body Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse	Extracellular Region Extracellular Space
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Binding Protein Homodimerization Activity Metal Ion Binding Oligopeptidase Activity Cardiolipin Binding	Hormone Activity Protein Binding
	Biological Process	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Learning Or Memory Substance P Catabolic Process Bradykinin Catabolic Process Protein Processing Sensory Perception Of Pain Protein Catabolic Process Lung Development Hormone Catabolic Process Response To Estrogen Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Food
Pathways		Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells	G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat	Oxetacaine
Diseases
GWAS		Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		20 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 SNCA TMEM132D VIP	24 interacting genes: AQP6 AQP9 ASPH BCL2L13 CISD2 CP CPE CREB3L1 CYB5R3 ERGIC3 FAM209A GOLM1 GPR152 KIR2DL3 KRT34 LHFPL2 MEP1B MMD MME MUC1 PDZK1IP1 PLP1 SLC10A1 TMEM52B
Entrez ID		4311	2520
HPRD ID		00392	00671
Ensembl ID		ENSG00000196549	ENSG00000184502
Uniprot IDs		P08473 Q3KQS6	A0A0E3VY36 P01350
PDB IDs		1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP	5WRJ 7F8V 7F8W 7XOW
Enriched GO Terms of Interacting Partners?		Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Biological Quality Positive Regulation Of Heart Contraction Intracellular Signal Transduction Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Metabolic Process Signaling Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Vascular Process In Circulatory System Extracellular Region Positive Regulation Of Small Molecule Metabolic Process Regulation Of Vasoconstriction Signal Release Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of Blood Pressure Circulatory System Process Negative Regulation Of MAPK Cascade Regulation Of Locomotion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Transport Regulation Of Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Secretion Protein Kinase CK2 Complex	Membrane
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