ZNF774 and NEK6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF774	NEK6
Description		zinc finger protein 774	NIMA related kinase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Protein Phosphorylation Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence
Pathways		Generic Transcription Pathway	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072) Rheumatoid arthritis ( 22446963)	Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)
Interacting Genes		77 interacting genes: BACH2 BEGAIN BLK BOLA2 BOLA2B CABP2 CALCOCO2 CARD9 CATSPER1 CCDC102B CCDC136 CCDC6 CCHCR1 CDK18 CDKN2D CEP63 CIB3 COL8A1 CPNE7 DTX2 DVL3 EFEMP2 EMD FAM124B FSD2 GABARAPL2 GEM GFAP GLRX3 GOLGA1 GOLGA2 GTPBP3 GYS1 GZMM HOXA1 HOXB5 HSF2BP IL16 IPO8 KANK2 KIFC3 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP4-5 LDOC1 LONRF1 MAGOHB MID2 MLH1 MTUS2 MYO15B NDOR1 NEK6 NID2 PIBF1 PICK1 PRPF31 PSMB1 RABEP1 RAD51D RBM11 SCNM1 SH2D4A SMAD3 STK16 TRAF2 TSTD2 USP49 VWC2 YJU2B ZNF165 ZNF417 ZNF48 ZNF526 ZNF572 ZNF587	119 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEBPA CEP76 CFP CIRSR COG6 CTBP2 DDIT4L DES DPH2 EFHC2 EML4 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SAXO5 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1
Entrez ID		342132	10783
HPRD ID		17571	05348
Ensembl ID		ENSG00000196391	ENSG00000119408
Uniprot IDs		Q6NX45	Q9HC98
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex	Protein Binding Cytoskeleton Intermediate Filament Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Binding DNA-binding Transcription Factor Activity Intermediate Filament Organization Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Centrosome DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleus Supramolecular Fiber Organization Negative Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Cytosol Ubiquitin Protein Ligase Activity DNA Binding Sno(s)RNA Catabolic Process Z Disc Intermediate Filament Cytoskeleton SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Cellular Component Organization Cell Differentiation Structural Constituent Of Cytoskeleton
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