DLG2 and KIF1B

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		DLG2	KIF1B
Description		discs large MAGUK scaffold protein 2	kinesin family member 1B
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Adherens Junction Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Neuromuscular Junction Cell Projection Neuron Projection Perikaryon Juxtaparanode Region Of Axon Synapse Postsynaptic Density Membrane Axon Cytoplasm	Cytoplasm Mitochondrion Cytoskeleton Kinesin Complex Microtubule Membrane Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Presynapse Postsynapse Axon Cytoplasm
	Molecular Function	GMP Kinase Activity Protein Binding Kinase Binding Protein Kinase Binding Ionotropic Glutamate Receptor Binding	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding
	Biological Process	Chemical Synaptic Transmission Nervous System Development Protein Localization To Synapse Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport	Apoptotic Process Microtubule-based Movement Neuron-neuron Synaptic Transmission Neuromuscular Synaptic Transmission Transport Along Microtubule Vesicle-mediated Transport Mitochondrion Transport Along Microtubule Anterograde Synaptic Vesicle Transport Apoptotic Process Involved In Development Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Familial squamous cell lung carcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 32201043 32310270 28892059 28011712 25064009 17052657) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Schizophrenia x sex interaction ( 34099189) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hepatitis B virus-related hepatocellular carcinoma ( 29246937) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Lateral orbital frontal cortex volume ( 31530798) Mean platelet volume ( 27863252 22139419 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 18997785) Neutrophil count ( 32888494) Platelet count ( 32888494) Virologic severity in Herpes simplex virus type 2 infection ( 29535370) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		54 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DSCAM ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VANGL2 VTN WNT3A	25 interacting genes: ARHGAP1 BRCA1 CALM1 CHP1 CLIP4 CPEB1 DLG1 DLG2 DLG3 DLG4 DSCR4 DYSF EEF1A1 GIPC1 LAMTOR5 PATJ PGM1 PKNOX1 POMP RSPH1 SIAH1 SNTA1 STARD13 TRIM55 YWHAG
Entrez ID		1740	23095
HPRD ID		04663	05818
Ensembl ID		ENSG00000150672	ENSG00000054523
Uniprot IDs		A0A3B3ISW2 A0A5F9ZH92 A0A994J570 A0A994J587 A0A994J5T6 A0A994J7P1 A0A994J7Q5 A0A994J819 A0A994J822 B5MCC5 B7Z2T4 E9PIJ9 E9PN83 Q15700	O60333
PDB IDs		2BYG 2HE2	2EH0
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Membrane PDZ Domain Binding Regulation Of Membrane Potential Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Chemical Synaptic Transmission Postsynaptic Density Trans-synaptic Signaling Modulation Of Chemical Synaptic Transmission Metal Ion Transport Modulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Glutamate Receptor Signaling Pathway Plasma Membrane Regulation Of System Process Protein Localization To Synapse Monoatomic Ion Transport Dendritic Spine Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Signaling Regulation Of Cell Communication Regulation Of Synapse Organization Protein Localization To Cell Junction Presynapse Assembly Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly Monoatomic Ion Channel Activity Inorganic Ion Transmembrane Transport NMDA Glutamate Receptor Activity Presynapse Organization Regulation Of Nervous System Process Calcium Ion Transport Synaptic Transmission, Glutamatergic	Establishment Or Maintenance Of Apical/basal Cell Polarity Kinase Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Cytoplasm Protein Localization To Cell Junction Postsynaptic Density Membrane Regulation Of Sodium Ion Transmembrane Transport Protein Kinase Binding Cytosol GMP Kinase Activity Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Regulation Of Sodium Ion Transport Cytoplasmic Microtubule Organization Synaptic Signaling GDP Metabolic Process Juxtaparanode Region Of Axon Adherens Junction Cellular Response To Potassium Ion Voltage-gated Potassium Channel Complex Ribonucleoside Diphosphate Metabolic Process Regulation Of Synaptic Plasticity Nucleoside Diphosphate Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Response To Potassium Ion Postsynaptic Density Regulation Of Cell Communication Regulation Of Signaling Regulation Of Monoatomic Cation Transmembrane Transport Sarcolemma Protein K6-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission GMP Metabolic Process AMPA Glutamate Receptor Complex Intracellular Signal Transduction Bicellular Tight Junction Regulation Of Monoatomic Ion Transmembrane Transport
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