DLG2 and GUCY1A2

Number of citations of the paper that reports this interaction (PMID 11572861)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DLG2	GUCY1A2
Gene Name		discs, large homolog 2 (Drosophila)	guanylate cyclase 1, soluble, alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane	Cytoplasm
	Molecular Function	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding	Guanylate Cyclase Activity GTP Binding Heme Binding
	Biological Process	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	CGMP Biosynthetic Process Signal Transduction Blood Coagulation Positive Regulation Of CGMP Biosynthetic Process Intracellular Signal Transduction
Pathways			Platelet homeostasis Nitric oxide stimulates guanylate cyclase
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)	Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A	8 interactors: DLG1 DLG2 DLG3 DLG4 ERBB2IP GUCY1B3 SNTA1 STUB1
Entrez ID		1740	2977
HPRD ID		04663	03146
Ensembl ID		ENSG00000150672	ENSG00000152402
Uniprot IDs		B7Z2T4 E9PN83 Q15700	B7ZLT5 P33402
PDB IDs		2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly	Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Nucleotide Phosphorylation Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Organophosphate Metabolic Process Synaptic Transmission Cellular Protein Localization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Membrane Organization Cell-cell Signaling Protein Localization Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Dephosphorylation Axon Guidance Signaling Regulation Of Ion Transmembrane Transport Cell Communication Regulation Of Vasoconstriction By Circulating Norepinephrine Small Molecule Metabolic Process Regulation Of Catalytic Activity Cellular Localization Regulation Of Phosphatase Activity Axonogenesis Positive Regulation Of Chaperone-mediated Protein Complex Assembly Basal Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Dephosphorylation Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Phosphate-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Synapse Organization Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production
Tagcloud ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?