DLG2 and NLGN3

Number of citations of the paper that reports this interaction (PMID 9278515)
105

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLG2	NLGN3
Gene Name		discs, large homolog 2 (Drosophila)	neuroligin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse
	Molecular Function	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding	Receptor Activity Protein Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Synapse Assembly Learning Metabolic Process Visual Learning Adult Behavior Social Behavior Axon Extension Oligodendrocyte Differentiation Regulation Of Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A	8 interactors: DLG2 DLG3 DLG4 MEOX2 NRXN1 NRXN2 NRXN3 PRDX2
Entrez ID		1740	54413
HPRD ID		04663	02275
Ensembl ID		ENSG00000150672	ENSG00000196338
Uniprot IDs		B7Z2T4 E9PN83 Q15700	D3DVV1 Q4G160 Q9NZ94
PDB IDs		2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly	Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synapse Assembly Synaptic Transmission Neuron Cell-cell Adhesion Protein Localization To Membrane Postsynaptic Membrane Organization Learning Cell-cell Signaling Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Vocal Learning Regulation Of Grooming Behavior Learning Or Memory Postsynaptic Membrane Assembly Cognition Postsynaptic Density Protein 95 Clustering Membrane Organization Auditory Behavior Neurotransmitter Secretion Axon Guidance Positive Regulation Of Synapse Maturation Single-organism Behavior Regulation Of Neurotransmitter Levels Regulation Of Synapse Maturation Secretion By Cell Neurological System Process Mechanosensory Behavior Axonogenesis Response To Auditory Stimulus Neurotransmitter Transport Adult Behavior Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Nervous System Development Membrane Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Cellular Localization Chemotaxis Cellular Protein Localization Membrane Biogenesis Secretion Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity
Tagcloud ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube
Tagcloud (Intersection) ?