DLG2 and FZD4

Number of citations of the paper that reports this interaction (PMID 12067714)
9

Data Source:
HPRD (two hybrid)

		DLG2	FZD4
Gene Name		discs, large homolog 2 (Drosophila)	frizzled class receptor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Protein Heterodimerization Activity
	Biological Process	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Vasculogenesis G-protein Coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Neuron Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Progesterone Secretion Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN WNT5A-dependent internalization of FZD4 Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A	7 interactors: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3
Entrez ID		1740	8322
HPRD ID		04663	05203
Ensembl ID		ENSG00000150672	ENSG00000174804
Uniprot IDs		B7Z2T4 E9PN83 Q15700	Q9ULV1
PDB IDs		2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Protein Localization To Membrane Protein Localization Nervous System Development Regulation Of Catalytic Activity Nucleotide Metabolic Process Cellular Protein Localization Regulation Of Phosphorus Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Signaling Cell Communication Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Organophosphate Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process System Development Positive Regulation Of JUN Kinase Activity Cellular Localization Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Sensory Perception Of Pain Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Synaptic Transmission Anatomical Structure Development Synaptic Transmission Positive Regulation Of Catalytic Activity Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	ameliorating c181r c204r c204y coexpression confocal correctable culturing exit exudative fevr fifteen frizzled g36n g488d glycosylation h69y haploinsufficiency inability localizations m105t m105v misfolding missense p33s polyubiquitination subcellular trafficking vitreoretinopathy
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	ameliorating c181r c204r c204y coexpression confocal correctable culturing exit exudative fevr fifteen frizzled g36n g488d glycosylation h69y haploinsufficiency inability localizations m105t m105v misfolding missense p33s polyubiquitination subcellular trafficking vitreoretinopathy
Tagcloud (Intersection) ?