DLG2 and ERBB4

Number of citations of the paper that reports this interaction (PMID 10725395)
52

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		DLG2	ERBB4
Gene Name		discs, large homolog 2 (Drosophila)	erb-b2 receptor tyrosine kinase 4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)	Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A	39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1
Entrez ID		1740	2066
HPRD ID		04663	02767
Ensembl ID		ENSG00000150672	ENSG00000178568
Uniprot IDs		B7Z2T4 E9PN83 Q15700	Q15303
PDB IDs		2BYG 2HE2	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade
Tagcloud ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg3 germline guanylate homology identity imaginal lethal mediating member neoplastic organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	180k 185k 45k activates erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Intersection) ?		encodes oncogene