VWA5A and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		VWA5A	RHOU
Description		von Willebrand factor A domain containing 5A	ras homolog family member U
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process		G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Aging (time to death) ( 21782286)	Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		6 interacting genes: APP MEOX2 PPARA PRTFDC1 RHOU SPSB1	126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		4013	58480
HPRD ID		04238	06965
Ensembl ID		ENSG00000110002	ENSG00000116574
Uniprot IDs		O00534	Q7L0Q8
PDB IDs			2Q3H
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Visual Behavior Visual Learning Circadian Regulation Of Gene Expression Associative Learning Circadian Rhythm Adult Behavior Positive Regulation Of Long-term Synaptic Potentiation Learning Regulation Of Neurotransmitter Uptake Negative Regulation Of MiRNA Transcription Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Receptor Internalization Lipoprotein Metabolic Process Regulation Of Synaptic Plasticity Positive Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Long-term Synaptic Potentiation Rhythmic Process Negative Regulation Of Blood Pressure Positive Regulation Of Gene Expression, Epigenetic Learning Or Memory Regulation Of Glycolytic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Receptor-mediated Endocytosis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Cognition Response To Metal Ion Response To Light Stimulus Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Carbohydrate Catabolic Process Regulation Of Multicellular Organism Growth Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Biological Quality Regulation Of Receptor Internalization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Adult Locomotory Behavior	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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