VWA5A and SPSB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VWA5A	SPSB1
Description		von Willebrand factor A domain containing 5A	splA/ryanodine receptor domain and SOCS box containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Aging (time to death) ( 21782286)	A body shape index ( 34021172) Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 31562340 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 30578418 27841878) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: APP MEOX2 PPARA PRTFDC1 RHOU SPSB1	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		4013	80176
HPRD ID		04238	18106
Ensembl ID		ENSG00000110002	ENSG00000171621
Uniprot IDs		O00534	Q96BD6
PDB IDs			2JK9 3F2O
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Visual Behavior Visual Learning Circadian Regulation Of Gene Expression Associative Learning Circadian Rhythm Adult Behavior Positive Regulation Of Long-term Synaptic Potentiation Learning Regulation Of Neurotransmitter Uptake Negative Regulation Of MiRNA Transcription Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Receptor Internalization Lipoprotein Metabolic Process Regulation Of Synaptic Plasticity Positive Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Long-term Synaptic Potentiation Rhythmic Process Negative Regulation Of Blood Pressure Positive Regulation Of Gene Expression, Epigenetic Learning Or Memory Regulation Of Glycolytic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Receptor-mediated Endocytosis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Cognition Response To Metal Ion Response To Light Stimulus Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Carbohydrate Catabolic Process Regulation Of Multicellular Organism Growth Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Biological Quality Regulation Of Receptor Internalization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Adult Locomotory Behavior	Negative Regulation Of Metabolic Process Chromatin Remodeling Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Chromatin Organization Regulation Of DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Gene Expression Transferase Activity Regulation Of DNA Recombination Histone H3 Methyltransferase Activity Negative Regulation Of Catabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Methyltransferase Activity Negative Regulation Of B Cell Activation Determination Of Adult Lifespan Regulation Of Cell Communication Regulation Of Signaling Regulation Of Megakaryocyte Differentiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Meiosis I Regulation Of Intracellular Signal Transduction Negative Regulation Of Double-strand Break Repair Methylation Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisomal Matrix Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Regulation Of Cellular Response To Stress Response To Starvation GATOR1 Complex Binding Hepatocyte Growth Factor Receptor Activity
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