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LDHA and ACD
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
LDHA
ACD
Description
lactate dehydrogenase A
ACD shelterin complex subunit and telomerase recruitment factor
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Sperm Fibrous Sheath
Extracellular Exosome
Oxidoreductase Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Telomerase Holoenzyme Complex
Nuclear Body
Shelterin Complex
Molecular Function
Catalytic Activity
Lactate Dehydrogenase Activity
L-lactate Dehydrogenase (NAD+) Activity
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Identical Protein Binding
Cadherin Binding
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
Telomeric DNA Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Lactate Metabolic Process
Glycolytic Process
Glucose Catabolic Process To Lactate Via Pyruvate
Carboxylic Acid Metabolic Process
Substantia Nigra Development
Pyruvate Catabolic Process
Telomere Maintenance
Skeletal System Development
Urogenital System Development
Intracellular Protein Transport
Telomere Maintenance Via Telomerase
Telomere Capping
Embryonic Limb Morphogenesis
Protection From Non-homologous End Joining At Telomere
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Segmentation
Protein Localization To Chromosome, Telomeric Region
Establishment Of Protein Localization To Telomere
Regulation Of Establishment Of Protein Localization To Telomere
Pathways
Pyruvate metabolism
Regulation of pyruvate metabolism
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
NADH
Etheno-NAD
Nicotinamide
Oxamic Acid
Stiripentol
Copper
Artenimol
Diseases
GWAS
Amyloid A serum levels (
21124955
)
Serum metabolite levels (
33031748
)
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
21 interacting genes:
ABCC9
ACD
CEBPA
DUX4
DYNLL1
FGFR1
GSK3A
HNRNPD
HULC
KCNJ11
MAPK10
NDRG1
PCNA
POT1
PTPRF
SRPK2
TERF1
TINF2
UPF2
XRN1
YWHAQ
64 interacting genes:
ACTB
ADPRH
AFAP1L2
AIPL1
ANKMY2
ANXA8L1
APOBEC3F
BAG3
CKB
CTTN
DBN1
DBNL
DCX
DPYSL3
EIF3G
EIF4B
ENO2
ENSA
FAM131B
FBXW7
FKBP6
GAPDH
HSP90AB1
IPO5
IVL
LASP1
LDHA
LGALSL
LLGL1
LRRC25
NCDN
NTAQ1
NUDC
NUDCD2
PAGE2
PDLIM2
PEX5
PFKP
PGM2
POT1
RBKS
RECQL4
RGS3
RPSA
SBDS
STIP1
STUB1
SULT1C2
TAGLN
TBC1D10A
TBCD
TINF2
TOMM34
TRIM15
TRIM16
TRIM55
TRIM63
TUBB2A
TUBB4B
USP7
XRCC6
YWHAE
ZFP36L1
ZNF790
Entrez ID
3939
65057
HPRD ID
01025
12417
Ensembl ID
ENSG00000134333
ENSG00000102977
Uniprot IDs
P00338
V9HWB9
A0A8Q3WM11
Q96AP0
PDB IDs
1I10
4AJP
4JNK
4L4R
4L4S
4M49
4OJN
4OKN
4QO7
4QO8
4QSM
4QT0
4R68
4R69
4RLS
4ZVV
5IXS
5IXY
5W8H
5W8I
5W8J
5W8K
5W8L
5ZJD
5ZJE
5ZJF
6BAD
6BAG
6BAX
6BAZ
6BB0
6BB1
6BB2
6BB3
6MV8
6MVA
6Q0D
6Q13
6SBU
6SBV
6ZZR
7M2N
8FW6
9BK2
9BK3
2I46
5H65
5I2X
5I2Y
5UN7
5XYF
7QXA
7QXB
7QXS
7S1T
7TRE
8SOJ
8SOK
Enriched GO Terms of Interacting Partners
?
Telomeric DNA Binding
Regulation Of DNA Biosynthetic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Telomere Maintenance Via Telomerase
Shelterin Complex
Nuclear Telomere Cap Complex
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance
Telomere Capping
Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Telomere Assembly
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of Telomere Maintenance
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Chromosome Organization
Telomere Maintenance
Positive Regulation Of Chromosome Organization
Negative Regulation Of Biosynthetic Process
Regulation Of Chromosome Organization
Telomere Organization
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Response To Metal Ion
Telomere Maintenance Via Telomerase
Negative Regulation Of Metabolic Process
Protein-containing Complex Binding
RNA-templated DNA Biosynthetic Process
DNA Biosynthetic Process
Nucleic Acid Metabolic Process
Telomere Maintenance Via Telomere Lengthening
Macromolecule Metabolic Process
Liver Development
Inward Rectifying Potassium Channel
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA Replication
Regeneration
ATP-activated Inward Rectifier Potassium Channel Activity
Regulation Of Establishment Of Protein Localization To Telomere
Positive Regulation Of DNA Biosynthetic Process
Response To Xenobiotic Stimulus
Positive Regulation Of Organelle Organization
Regulation Of Establishment Of Protein Localization To Chromosome
Telomerase Inhibitor Activity
Establishment Of Protein Localization To Telomere
Cytoplasm
Cytosol
Cadherin Binding
Carbohydrate Catabolic Process
Nuclear Telomere Cap Complex
Protein Folding Chaperone Complex
Substantia Nigra Development
ADP Catabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Glycolytic Process
Telomere Maintenance
Cellular Response To Heat
ADP Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Nucleoside Diphosphate Catabolic Process
Monosaccharide Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
Unfolded Protein Binding
Telomeric D-loop Binding
Telomere Assembly
Organelle Organization
Neural Nucleus Development
Pyruvate Metabolic Process
Glucose Metabolic Process
Telomere Organization
Protein Folding
Cortical Cytoskeleton
Glucose Catabolic Process
Telomeric DNA Binding
Protein Binding
Shelterin Complex
Ribonucleoside Diphosphate Metabolic Process
Purine Ribonucleotide Catabolic Process
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Cytoskeleton Organization
Cytoskeleton
Microtubule Cytoskeleton Organization
Nucleoside Diphosphate Metabolic Process
Protein Stabilization
Chaperone-mediated Autophagy
Microtubule
Response To Heat
Purine Nucleotide Catabolic Process
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Hexose Metabolic Process
Microtubule Cytoskeleton
Intercellular Bridge
Telomeric D-loop Disassembly
Hsp90 Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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