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ACD and NUDCD2
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
ACD
NUDCD2
Description
ACD shelterin complex subunit and telomerase recruitment factor
NudC domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Telomerase Holoenzyme Complex
Nuclear Body
Shelterin Complex
Chromosome, Centromeric Region
Kinetochore
Spindle Pole
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule Cytoskeleton
Intercellular Bridge
Mitotic Spindle
Molecular Function
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
Telomeric DNA Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Protein Binding
Unfolded Protein Binding
Biological Process
Telomere Maintenance
Skeletal System Development
Urogenital System Development
Intracellular Protein Transport
Telomere Maintenance Via Telomerase
Telomere Capping
Embryonic Limb Morphogenesis
Protection From Non-homologous End Joining At Telomere
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Segmentation
Protein Localization To Chromosome, Telomeric Region
Establishment Of Protein Localization To Telomere
Regulation Of Establishment Of Protein Localization To Telomere
Protein Folding
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
64 interacting genes:
ACTB
ADPRH
AFAP1L2
AIPL1
ANKMY2
ANXA8L1
APOBEC3F
BAG3
CKB
CTTN
DBN1
DBNL
DCX
DPYSL3
EIF3G
EIF4B
ENO2
ENSA
FAM131B
FBXW7
FKBP6
GAPDH
HSP90AB1
IPO5
IVL
LASP1
LDHA
LGALSL
LLGL1
LRRC25
NCDN
NTAQ1
NUDC
NUDCD2
PAGE2
PDLIM2
PEX5
PFKP
PGM2
POT1
RBKS
RECQL4
RGS3
RPSA
SBDS
STIP1
STUB1
SULT1C2
TAGLN
TBC1D10A
TBCD
TINF2
TOMM34
TRIM15
TRIM16
TRIM55
TRIM63
TUBB2A
TUBB4B
USP7
XRCC6
YWHAE
ZFP36L1
ZNF790
5 interacting genes:
ACD
MYH9
POT1
TERF1
TINF2
Entrez ID
65057
134492
HPRD ID
12417
14058
Ensembl ID
ENSG00000102977
ENSG00000170584
Uniprot IDs
A0A8Q3WM11
Q96AP0
Q8WVJ2
PDB IDs
2I46
5H65
5I2X
5I2Y
5UN7
5XYF
7QXA
7QXB
7QXS
7S1T
7TRE
8SOJ
8SOK
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Cytosol
Cadherin Binding
Carbohydrate Catabolic Process
Nuclear Telomere Cap Complex
Protein Folding Chaperone Complex
Substantia Nigra Development
ADP Catabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Glycolytic Process
Telomere Maintenance
Cellular Response To Heat
ADP Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Nucleoside Diphosphate Catabolic Process
Monosaccharide Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
Unfolded Protein Binding
Telomeric D-loop Binding
Telomere Assembly
Organelle Organization
Neural Nucleus Development
Pyruvate Metabolic Process
Glucose Metabolic Process
Telomere Organization
Protein Folding
Cortical Cytoskeleton
Glucose Catabolic Process
Telomeric DNA Binding
Protein Binding
Shelterin Complex
Ribonucleoside Diphosphate Metabolic Process
Purine Ribonucleotide Catabolic Process
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Cytoskeleton Organization
Cytoskeleton
Microtubule Cytoskeleton Organization
Nucleoside Diphosphate Metabolic Process
Protein Stabilization
Chaperone-mediated Autophagy
Microtubule
Response To Heat
Purine Nucleotide Catabolic Process
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Hexose Metabolic Process
Microtubule Cytoskeleton
Intercellular Bridge
Telomeric D-loop Disassembly
Hsp90 Protein Binding
Shelterin Complex
Nuclear Telomere Cap Complex
Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomerase
Telomeric DNA Binding
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Telomere Assembly
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Chromosome Organization
Regulation Of DNA Biosynthetic Process
Telomere Maintenance
Positive Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
Telomere Organization
Negative Regulation Of DNA Metabolic Process
Telomere Maintenance Via Telomerase
RNA-templated DNA Biosynthetic Process
Telomere Maintenance Via Telomere Lengthening
Chromosome, Telomeric Region
Regulation Of Chromosome Organization
Positive Regulation Of DNA Metabolic Process
Chromosome Organization
Nuclear Body
Regulation Of Establishment Of Protein Localization To Telomere
Regulation Of Establishment Of Protein Localization To Chromosome
DNA Biosynthetic Process
Telomerase Inhibitor Activity
Establishment Of Protein Localization To Telomere
Telomeric D-loop Disassembly
G-rich Strand Telomeric DNA Binding
Regulation Of DNA Metabolic Process
Telomeric Loop Disassembly
Positive Regulation Of Organelle Organization
Protein Localization To Chromosome, Telomeric Region
Chromosome
Negative Regulation Of Cellular Component Organization
DNA Metabolic Process
Regulation Of Cellular Component Organization
Organelle Organization
Positive Regulation Of Cellular Component Organization
Regulation Of Organelle Organization
Positive Regulation Of Macromolecule Metabolic Process
Cortical Granule Exocytosis
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
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Tagcloud (Intersection)
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