ACD and RECQL4

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		ACD	RECQL4
Gene Name		adrenocortical dysplasia homolog (mouse)	RecQ protein-like 4
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Membrane
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	Bubble DNA Binding ATP Binding Zinc Ion Binding Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity
	Biological Process	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region	DNA Strand Renaturation DNA Replication DNA Repair DNA Recombination Multicellular Organismal Development DNA Duplex Unwinding
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		59 interactors: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	6 interactors: ACD EP300 POT1 PRSS23 TERF1 TERF2IP
Entrez ID		65057	9401
HPRD ID		12417	04805
Ensembl ID		ENSG00000102977	ENSG00000160957
Uniprot IDs		Q96AP0	O94761
PDB IDs		2I46	2KMU
Enriched GO Terms of Interacting Partners?		Organelle Organization Protein Folding Carbohydrate Catabolic Process Substantia Nigra Development Neural Nucleus Development 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Nervous System Development Catabolic Process Cellular Component Assembly Midbrain Development Glycolytic Process Multicellular Organismal Development Negative Regulation Of Telomere Maintenance Via Telomerase Generation Of Neurons Telomere Assembly Pyruvate Metabolic Process Neurogenesis Developmental Process Negative Regulation Of Telomere Maintenance Monosaccharide Metabolic Process Regulation Of Cellular Protein Metabolic Process Brain Development Cellular Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Head Development Glucose Metabolic Process Neuron Projection Development Neuron Projection Morphogenesis Telomere Maintenance Cell Differentiation Neuron Differentiation Regulation Of Protein Metabolic Process System Development DNA Duplex Unwinding DNA Geometric Change Regulation Of Telomere Maintenance Cellular Process Neuron Development Adherens Junction Organization Central Nervous System Development Pathogenesis Hexose Metabolic Process Cellular Carbohydrate Metabolic Process Negative Regulation Of DNA Metabolic Process Protein Polymerization Regulation Of Signaling Innate Immune Response DNA Metabolic Process	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Assembly Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Chromosome Organization Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome DNA Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Organelle Organization DNA Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Biosynthetic Process Homeostatic Process Organelle Organization Histone H2B Acetylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Segmentation G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Telomeric Loop Formation Age-dependent Telomere Shortening N-terminal Peptidyl-lysine Acetylation Telomere Formation Via Telomerase Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Shortening Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Tagcloud ?		acpra apng1 arg52 betaherpesvirus capsid carboxy carboxyl ccd corroborated counterparts cytomegalovirus deleting gal4 gammaherpesvirus hcmv his34 homologs maturational mcp pap proteinase replace scmv simian substituting transporting ul80 ul80a ul86	baller col2a1 conditional copyright craniofacial craniosynostosis cre developmental fl gerold helicases inactivation limb mimicking plate protected prx1 radial rapadilino rescue reserved rights rothmund skeletal thomson transgene trp53
Tagcloud (Difference) ?		acpra apng1 arg52 betaherpesvirus capsid carboxy carboxyl ccd corroborated counterparts cytomegalovirus deleting gal4 gammaherpesvirus hcmv his34 homologs maturational mcp pap proteinase replace scmv simian substituting transporting ul80 ul80a ul86	baller col2a1 conditional copyright craniofacial craniosynostosis cre developmental fl gerold helicases inactivation limb mimicking plate protected prx1 radial rapadilino rescue reserved rights rothmund skeletal thomson transgene trp53
Tagcloud (Intersection) ?