LDHA and ABCC9

Number of citations of the paper that reports this interaction (PMID 12145195)
34

Data Source:
HPRD (in vivo)

		LDHA	ABCC9
Gene Name		lactate dehydrogenase A	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Vesicular Exosome	Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Sarcomere Sarcolemma
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding	Transporter Activity Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity Potassium Channel Regulator Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding
	Biological Process	Pyruvate Metabolic Process Glycolytic Process Substantia Nigra Development Cellular Response To Extracellular Stimulus Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Potassium Ion Transport Signal Transduction Synaptic Transmission Metabolic Process Potassium Ion Import Defense Response To Virus Transmembrane Transport
Pathways		Pyruvate metabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Inwardly rectifying K+ channels ABC-family proteins mediated transport ATP sensitive Potassium channels Potassium Channels
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Etheno-Nad Nicotinamide Oxamic Acid	Adenosine triphosphate Glyburide
Diseases
GWAS		Amyloid A Levels ( 21124955)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ABCC9 ACD DYNLL1 HNRNPD KCNJ11 LDHB MAPK10 NDRG1 PCNA POT1 TERF1 TINF2 UPF2 XRN1 YWHAQ	5 interactors: EEF1G KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3939	10060
HPRD ID		01025	03258
Ensembl ID		ENSG00000134333	ENSG00000069431
Uniprot IDs		P00338	O60706
PDB IDs		1I10 4AJP 4JNK 4M49
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Telomere Assembly Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Regulation Of Chromosome Organization Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process RNA-dependent DNA Replication Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Potassium Ion Import Homeostatic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Localization To Chromosome Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Chromosome Organization DNA Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Neural Nucleus Development Cell Cycle Phase Transition Positive Regulation Of Mitochondrion Organization DNA Replication Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation	Potassium Ion Import Generation Of Precursor Metabolites And Energy Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Potassium Ion Transmembrane Transport Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Response To Virus Regulation Of Hormone Secretion Regulation Of Membrane Potential Cellular Response To Nicotine Energy Derivation By Oxidation Of Organic Compounds Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Fusion To Presynaptic Membrane Oxidation-reduction Process Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Response To Gravity Positive Regulation Of Neurotransmitter Secretion Ion Transport Response To External Stimulus Response To Stimulus Glutamate Secretion Response To ATP Regulation Of Ion Transport Regulation Of Protein Transport Positive Regulation Of Cation Channel Activity Regulation Of Secretion Vasodilation Response To Ischemia Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Monovalent Inorganic Cation Transport Response To PH Regulation Of Establishment Of Protein Localization Response To Testosterone Substantia Nigra Development Response To Nicotine Cellular Response To Alkaloid Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Response To Other Organism Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Positive Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Biotic Stimulus
Tagcloud ?		11p 11q assignment cat chromosomes ets1 hbb homologous homology hras1 hsa hybrids ins karyotype karyotypes karyotypically loci monkey owl panels portion primate pth rodent segregation shared syntenic thy1 vi	annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide
Tagcloud (Difference) ?		11p 11q assignment cat chromosomes ets1 hbb homologous homology hras1 hsa hybrids ins karyotype karyotypes karyotypically loci monkey owl panels portion primate pth rodent segregation shared syntenic thy1 vi	annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide
Tagcloud (Intersection) ?