LDHA and ABCC9

Number of citations of the paper that reports this interaction (PubMedID 12145195)
32

Data Source:
HPRD (in vivo)

		LDHA	ABCC9
Description		lactate dehydrogenase A	ATP binding cassette subfamily C member 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Exosome Oxidoreductase Complex	Cytoplasm Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Sarcomere Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma
	Molecular Function	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Cadherin Binding	Nucleotide Binding Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Transmembrane Transporter Binding Protein-containing Complex Binding Potassium Channel Activator Activity ABC-type Transporter Activity
	Biological Process	Lactate Metabolic Process Glycolytic Process Glucose Catabolic Process To Lactate Via Pyruvate Carboxylic Acid Metabolic Process Substantia Nigra Development Pyruvate Catabolic Process	MAPK Cascade Action Potential Blood Vessel Development Response To Hypoxia Heart Morphogenesis Vascular Process In Circulatory System Regulation Of Transcription By RNA Polymerase II Potassium Ion Transport Response To Stress Mitochondrion Organization Heart Development Skeletal Muscle Tissue Development Blood Circulation Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Response To Activity Fatty Acid Oxidation Response To ATP Response To Potassium Ion Cellular Response To Potassium Ion Response To Decreased Oxygen Levels Vasodilation Regulation Of Membrane Potential Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Response To Estrogen Cellular Respiration Negative Regulation Of Blood Pressure ATP Metabolic Process Fibroblast Proliferation Defense Response To Virus Transmembrane Transport Coronary Vasculature Development Cardiac Conduction Cellular Response To Chemical Stress Response To Oxygen Levels Cellular Response To Calcium Ion Cellular Response To ATP Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Circulatory System Development Oxygen Metabolic Process Cardiac Muscle Cell Contraction Blood Vessel Diameter Maintenance Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Across Blood-brain Barrier Regulation Of Potassium Ion Transmembrane Transport Response To Peptide Reactive Oxygen Species Biosynthetic Process Response To Hydrogen Sulfide Potassium Ion Import Across Plasma Membrane
Pathways		Pyruvate metabolism Regulation of pyruvate metabolism	ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Drugs		NADH Etheno-NAD Nicotinamide Oxamic Acid Stiripentol Copper Artenimol	ATP Glyburide Nicorandil
Diseases			Atrial fibrillation
GWAS		Amyloid A serum levels ( 21124955) Serum metabolite levels ( 33031748)	Appendicular lean mass ( 33097823) Birth weight ( 27680694) Gout ( 22179738) Hippocampal sclerosis of aging ( 24770881) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418)
Interacting Genes		21 interacting genes: ABCC9 ACD CEBPA DUX4 DYNLL1 FGFR1 GSK3A HNRNPD HULC KCNJ11 MAPK10 NDRG1 PCNA POT1 PTPRF SRPK2 TERF1 TINF2 UPF2 XRN1 YWHAQ	6 interacting genes: EEF1G HSPB2 KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3939	10060
HPRD ID		01025	03258
Ensembl ID		ENSG00000134333	ENSG00000069431
Uniprot IDs		P00338 V9HWB9	O60706
PDB IDs		1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L 5ZJD 5ZJE 5ZJF 6BAD 6BAG 6BAX 6BAZ 6BB0 6BB1 6BB2 6BB3 6MV8 6MVA 6Q0D 6Q13 6SBU 6SBV 6ZZR 7M2N 8FW6 9BK2 9BK3
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Capping Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Regulation Of Chromosome Organization Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Response To Metal Ion Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Protein-containing Complex Binding RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Macromolecule Metabolic Process Liver Development Inward Rectifying Potassium Channel Nucleobase-containing Compound Metabolic Process Regulation Of DNA Replication Regeneration ATP-activated Inward Rectifier Potassium Channel Activity Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere	Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Presynaptic Active Zone Membrane Response To ATP Determination Of Adult Lifespan Potassium Ion Import Across Plasma Membrane Response To Ischemia Cardiac Muscle Tissue Development Atrioventricular Node Cell Differentiation Myosin Head/neck Binding Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Inorganic Cation Import Across Plasma Membrane Neurotransmitter Transport Protein Localization To Extracellular Region Potassium Ion-transporting ATPase Complex Synaptic Assembly At Neuromuscular Junction Striated Muscle Tissue Development Cardiac Pacemaker Cell Differentiation Action Potential Establishment Of Protein Localization To Extracellular Region Protein Secretion Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Glutamate Secretion, Neurotransmission Glucose Metabolic Process Lactate Dehydrogenase Activity Glucose Catabolic Process To Lactate Via Pyruvate Asymmetric Neuroblast Division Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Transmembrane Transporter Binding Somatic Muscle Development Import Across Plasma Membrane Potassium Ion Transmembrane Transport Import Into Cell Response To Purine-containing Compound Muscle Tissue Development L-lactate Dehydrogenase (NAD+) Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Calcium-mediated Signaling
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