ACD and EIF3G

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		ACD	EIF3G
Gene Name		adrenocortical dysplasia homolog (mouse)	eukaryotic translation initiation factor 3, subunit G
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		59 interactors: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	22 interactors: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 MPHOSPH6 MPP6 PIN1 PKN2 POT1 SMN1 SNCA TK1
Entrez ID		65057	8666
HPRD ID		12417	04886
Ensembl ID		ENSG00000102977	ENSG00000130811
Uniprot IDs		Q96AP0	O75821
PDB IDs		2I46	2CQ0
Enriched GO Terms of Interacting Partners?		Organelle Organization Protein Folding Carbohydrate Catabolic Process Substantia Nigra Development Neural Nucleus Development 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Nervous System Development Catabolic Process Cellular Component Assembly Midbrain Development Glycolytic Process Multicellular Organismal Development Negative Regulation Of Telomere Maintenance Via Telomerase Generation Of Neurons Telomere Assembly Pyruvate Metabolic Process Neurogenesis Developmental Process Negative Regulation Of Telomere Maintenance Monosaccharide Metabolic Process Regulation Of Cellular Protein Metabolic Process Brain Development Cellular Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Head Development Glucose Metabolic Process Neuron Projection Development Neuron Projection Morphogenesis Telomere Maintenance Cell Differentiation Neuron Differentiation Regulation Of Protein Metabolic Process System Development DNA Duplex Unwinding DNA Geometric Change Regulation Of Telomere Maintenance Cellular Process Neuron Development Adherens Junction Organization Central Nervous System Development Pathogenesis Hexose Metabolic Process Cellular Carbohydrate Metabolic Process Negative Regulation Of DNA Metabolic Process Protein Polymerization Regulation Of Signaling Innate Immune Response DNA Metabolic Process	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Ribonucleoprotein Complex Biogenesis Cellular Component Assembly Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Protein Metabolic Process Formation Of Cytoplasmic Translation Initiation Complex Translation Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Positive Regulation Of Telomerase Activity Cytoplasmic Translational Initiation Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Cytoplasmic Translation Negative Regulation Of Chromosome Organization Regulation Of Binding Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Maturation Of 5.8S RRNA Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Regulation Of Metabolic Process Response To Copper Ion Positive Regulation Of Catalytic Activity Gene Expression Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Ribosome Biogenesis Protein Metabolic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation
Tagcloud ?		acpra apng1 arg52 betaherpesvirus capsid carboxy carboxyl ccd corroborated counterparts cytomegalovirus deleting gal4 gammaherpesvirus hcmv his34 homologs maturational mcp pap proteinase replace scmv simian substituting transporting ul80 ul80a ul86	bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translation translational validated yeast zinc
Tagcloud (Difference) ?		acpra apng1 arg52 betaherpesvirus capsid carboxy carboxyl ccd corroborated counterparts cytomegalovirus deleting gal4 gammaherpesvirus hcmv his34 homologs maturational mcp pap proteinase replace scmv simian substituting transporting ul80 ul80a ul86	bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translation translational validated yeast zinc
Tagcloud (Intersection) ?