ACD and IPO5

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		ACD	IPO5
Description		ACD shelterin complex subunit and telomerase recruitment factor	importin 5
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex	Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell Cycle Cellular Response To Amino Acid Stimulus
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	vRNP Assembly
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Peripheral artery disease ( 26488411) Smooth-surface caries ( 24556642)
Interacting Genes		64 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	31 interacting genes: ACD CAB39 CDC42 DPPA3 DTNBP1 GPRASP3 H1-0 NOSIP NRIP1 NUP153 NUP214 NUP62 NUP98 OGT PRRC2B PTEN RAG2 RAN RANBP2 RNF10 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL
Entrez ID		65057	3843
HPRD ID		12417	03597
Ensembl ID		ENSG00000102977	ENSG00000065150
Uniprot IDs		A0A8Q3WM11 Q96AP0	B3KWG6 O00410 Q9BVS9
PDB IDs		2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK	6XTE 6XU2 9IM6
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding	Cytosolic Ribosome Import Into Nucleus Protein Import Into Nucleus Cytoplasmic Translation Establishment Of Protein Localization To Organelle Nuclear Pore Nucleus Ribonucleoprotein Complex Protein Localization To Nucleus Cytosolic Large Ribosomal Subunit Structural Constituent Of Nuclear Pore RNA Binding Protein Localization To Organelle Nuclear Export Shelterin Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Structural Constituent Of Ribosome RNA Export From Nucleus Nucleolus Negative Regulation Of Ubiquitin Protein Ligase Activity Nuclear Telomere Cap Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleoplasm Ribosome Nuclear Inclusion Body Ubiquitin Ligase Inhibitor Activity Telomere Capping Nuclear Pore Nuclear Basket Nucleobase-containing Compound Transport Nuclear Envelope Translation MRNA Transport Intracellular Transport Intracellular Protein Transport Dendritic Spine Morphogenesis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Localization Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear Localization Sequence Binding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Organelle Localization Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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