LDHA and PTPRF

Number of citations: 51 (PubMedID 25458010)
Data Source: BioGRID (two hybrid)

		LDHA	PTPRF
Name		lactate dehydrogenase A	protein tyrosine phosphatase receptor type F
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Exosome Oxidoreductase Complex	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Cadherin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Hydrolase Activity Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Lactate Metabolic Process Glycolytic Process Glucose Catabolic Process To Lactate Via Pyruvate Carboxylic Acid Metabolic Process Substantia Nigra Development Pyruvate Catabolic Process	Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Regulation Of Neuron Projection Development Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding
Pathways		Pyruvate metabolism Regulation of pyruvate metabolism	Receptor-type tyrosine-protein phosphatases Insulin receptor recycling Synaptic adhesion-like molecules
Drugs		NADH Etheno-NAD Nicotinamide Oxamic Acid Stiripentol Copper Artenimol	None
GWAS		Amyloid A serum levels ( 21124955 ) Serum metabolite levels ( 33031748 )	Adventurousness ( 30643258 ) Amyotrophic lateral sclerosis (age of onset) ( 22959728 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Attention deficit hyperactivity disorder ( 33495439 30478444 ) Attention deficit hyperactivity disorder or cannabis use ( 30610198 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Coffee consumption ( 31046077 ) Cognitive ability (MTAG) ( 29186694 ) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439 ) Educational attainment ( 27046643 ) General cognitive ability ( 29844566 ) General risk tolerance (MTAG) ( 30643258 ) Household income (MTAG) ( 31844048 ) Intake of total sugars ( 31005972 ) Intelligence (MTAG) ( 29326435 ) Mean reticulocyte volume ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 30285260 29483656 28991256 25056061 ) Smoking initiation ( 30617275 33082346 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Urate levels ( 31578528 )
Interacting Genes		21 interacting genes: ABCC9 ACD CEBPA DUX4 DYNLL1 FGFR1 GSK3A HNRNPD HULC KCNJ11 MAPK10 NDRG1 PCNA POT1 PTPRF SRPK2 TERF1 TINF2 UPF2 XRN1 YWHAQ	59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 OMG PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B VCAN ZNF512B
Entrez ID		3939	5792
HPRD ID		01025	01552
Ensembl ID		ENSG00000134333	ENSG00000142949
Uniprot IDs		P00338 V9HWB9	G1UI20 P10586
PDB IDs		1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L 5ZJD 5ZJE 5ZJF 6BAD 6BAG 6BAX 6BAZ 6BB0 6BB1 6BB2 6BB3 6MV8 6MVA 6Q0D 6Q13 6SBU 6SBV 6ZZR 7M2N 8FW6 9BK2 9BK3	1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW
GO Terms Enriched among Interactors		Telomeric DNA Binding Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Capping Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Regulation Of Chromosome Organization Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Response To Metal Ion Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Protein-containing Complex Binding RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Macromolecule Metabolic Process Liver Development Inward Rectifying Potassium Channel Nucleobase-containing Compound Metabolic Process Regulation Of DNA Replication Regeneration ATP-activated Inward Rectifier Potassium Channel Activity Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere	Extracellular Exosome Protein Refolding Phosphatidylinositol 3-kinase Binding ATP-dependent Protein Folding Chaperone Focal Adhesion Perineuronal Net Disordered Domain Specific Binding Protein Folding Chaperone Cell Adhesion Regulation Of Developmental Process Regulation Of Cellular Component Organization Regulation Of Protein Localization Cellular Response To Indole-3-methanol Tau Protein Binding Response To Indole-3-methanol Lysosomal Lumen Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Motility Regulation Of Locomotion Cadherin Binding Regulation Of Signal Transduction Apical Junction Complex Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Heat Shock Protein Binding Unfolded Protein Binding Cellular Response To Oxygen-containing Compound Nucleotide Binding Plasma Membrane Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Regulation Of Intrinsic Apoptotic Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Cell Migration ATP Hydrolysis Activity Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Presynaptic Active Zone Positive Regulation Of Locomotion Regulation Of Cell Migration Ubiquitin Protein Ligase Binding Substantia Nigra Development Regulation Of Multicellular Organismal Development Response To Hormone Regulation Of Apoptotic Process