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LDHA and GSK3A
Number of citations of the paper that reports this interaction (PubMedID
30824926
)
69
Data Source:
BioGRID
(two hybrid)
LDHA
GSK3A
Description
lactate dehydrogenase A
glycogen synthase kinase 3 alpha
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Sperm Fibrous Sheath
Extracellular Exosome
Oxidoreductase Complex
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Axon
Beta-catenin Destruction Complex
Neuronal Cell Body
Apical Dendrite
Postsynapse
Proximal Dendrite
Molecular Function
Catalytic Activity
Lactate Dehydrogenase Activity
L-lactate Dehydrogenase (NAD+) Activity
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Identical Protein Binding
Cadherin Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase A Catalytic Subunit Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
Lactate Metabolic Process
Glycolytic Process
Glucose Catabolic Process To Lactate Via Pyruvate
Carboxylic Acid Metabolic Process
Substantia Nigra Development
Pyruvate Catabolic Process
Regulation Of Systemic Arterial Blood Pressure
Cardiac Left Ventricle Morphogenesis
Glycogen Metabolic Process
Nervous System Development
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of UDP-glucose Catabolic Process
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Cell Migration
Viral Protein Processing
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of TOR Signaling
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Cellular Response To Interleukin-3
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Heart Contraction
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of D-glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Excitatory Postsynaptic Potential
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Lithium Ion
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Autosome Genomic Imprinting
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitophagy
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Establishment Of Protein Localization
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Pathways
Pyruvate metabolism
Regulation of pyruvate metabolism
AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
Suppression of apoptosis
Maturation of nucleoprotein
Maturation of nucleoprotein
Drugs
NADH
Etheno-NAD
Nicotinamide
Oxamic Acid
Stiripentol
Copper
Artenimol
Fostamatinib
Diseases
GWAS
Amyloid A serum levels (
21124955
)
Serum metabolite levels (
33031748
)
Meat-related diet (
32066663
)
Interacting Genes
21 interacting genes:
ABCC9
ACD
CEBPA
DUX4
DYNLL1
FGFR1
GSK3A
HNRNPD
HULC
KCNJ11
MAPK10
NDRG1
PCNA
POT1
PTPRF
SRPK2
TERF1
TINF2
UPF2
XRN1
YWHAQ
76 interacting genes:
AKAP11
AKT1
ALKBH3
AP3D1
AURKAIP1
BCCIP
BCL2L1
BCL3
BICD1
C11orf98
CCDC174
CHTOP
CNTROB
CREB1
CREM
DCAF8
DDI1
DEAF1
DNAJB1
DRC1
EBNA1BP2
EIF2B5
FAM193B
GLI3
GOLGA6C
H2AZ2
HMBS
HMGN1
HNRNPM
HSF1
HSP90AA1
HSP90AB1
LCOR
LDHA
LRP6
LRRC37A2
LRSAM1
MAEA
MAPT
MCL1
MTCH1
MYC
MYL12A
NBR1
OGT
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
PRKCH
PRKCZ
PRKD3
PRKDC
PSMD8
PTMA
PXN
RICTOR
RPL15
RPL19
RPL29
RPS15
RPS19
RUNX1
SBNO1
SGK1
SGK3
SMARCA5
SMG7
SPG21
STAT2
SUGP2
TTC16
UBTF
VCPIP1
YWHAG
Entrez ID
3939
2931
HPRD ID
01025
06002
Ensembl ID
ENSG00000134333
ENSG00000105723
Uniprot IDs
P00338
V9HWB9
P49840
PDB IDs
1I10
4AJP
4JNK
4L4R
4L4S
4M49
4OJN
4OKN
4QO7
4QO8
4QSM
4QT0
4R68
4R69
4RLS
4ZVV
5IXS
5IXY
5W8H
5W8I
5W8J
5W8K
5W8L
5ZJD
5ZJE
5ZJF
6BAD
6BAG
6BAX
6BAZ
6BB0
6BB1
6BB2
6BB3
6MV8
6MVA
6Q0D
6Q13
6SBU
6SBV
6ZZR
7M2N
8FW6
9BK2
9BK3
7SXF
7SXG
Enriched GO Terms of Interacting Partners
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Telomeric DNA Binding
Regulation Of DNA Biosynthetic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Telomere Maintenance Via Telomerase
Shelterin Complex
Nuclear Telomere Cap Complex
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance
Telomere Capping
Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Telomere Assembly
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of Telomere Maintenance
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Chromosome Organization
Telomere Maintenance
Positive Regulation Of Chromosome Organization
Negative Regulation Of Biosynthetic Process
Regulation Of Chromosome Organization
Telomere Organization
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Response To Metal Ion
Telomere Maintenance Via Telomerase
Negative Regulation Of Metabolic Process
Protein-containing Complex Binding
RNA-templated DNA Biosynthetic Process
DNA Biosynthetic Process
Nucleic Acid Metabolic Process
Telomere Maintenance Via Telomere Lengthening
Macromolecule Metabolic Process
Liver Development
Inward Rectifying Potassium Channel
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA Replication
Regeneration
ATP-activated Inward Rectifier Potassium Channel Activity
Regulation Of Establishment Of Protein Localization To Telomere
Positive Regulation Of DNA Biosynthetic Process
Response To Xenobiotic Stimulus
Positive Regulation Of Organelle Organization
Regulation Of Establishment Of Protein Localization To Chromosome
Telomerase Inhibitor Activity
Establishment Of Protein Localization To Telomere
Diacylglycerol-dependent Serine/threonine Kinase Activity
Response To Peptide Hormone
Negative Regulation Of Apoptotic Process
Cytosol
Negative Regulation Of Programmed Cell Death
Regulation Of Programmed Cell Death
Response To Heat
Regulation Of Apoptotic Process
Response To Hormone
Macromolecule Metabolic Process
Nucleoplasm
Protein Phosphorylation
Protein Serine Kinase Activity
Nucleus
Cytoplasmic Translation
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Cellular Response To Heat
Phosphorylation
Protein Serine/threonine Kinase Activity
Cellular Response To Stress
Protein Kinase C Signaling
Response To Temperature Stimulus
Positive Regulation Of Immune System Process
Cytoplasm
Protein Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Response To Stress
Intracellular Signal Transduction
Protein Kinase Activity
Leukocyte Apoptotic Process
Positive Regulation Of Leukocyte Differentiation
Translation
Macromolecule Biosynthetic Process
Positive Regulation Of Protein Localization
Positive Regulation Of Metabolic Process
Nitric-oxide Synthase Regulator Activity
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Translation
Cellular Response To Oxygen-containing Compound
Protein Serine/threonine/tyrosine Kinase Activity
CAMP/PKA Signal Transduction
DNA Damage Response
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Protein Localization
Nucleic Acid Metabolic Process
Regulation Of Cellular Component Organization
Regulation Of Immune System Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Metabolic Process
Kinase Activity
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Tagcloud (Intersection)
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