ACD and TUBB2A

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		ACD	TUBB2A
Description		ACD shelterin complex subunit and telomerase recruitment factor	tubulin beta 2A class IIa
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Cerebral Cortex Development
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 27863252 32888494)
Interacting Genes		64 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	28 interacting genes: ACD ARL15 ARNT CHGB DISC1 DUX4 HGS HMMR LAMA4 LINC01554 OGT PAFAH1B3 POT1 PSMD11 PTPRS RABAC1 RIC8A RPA2 RPLP1 RSPH1 SAT1 SDC3 SERPINB9 TERF1 TK1 TNIK TPT1 UPF2
Entrez ID		65057	7280
HPRD ID		12417
Ensembl ID		ENSG00000102977	ENSG00000137267
Uniprot IDs		A0A8Q3WM11 Q96AP0	Q13885
PDB IDs		2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK	7NVN 8V3O 8V3P
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding	Telomeric DNA Binding Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric D-loop Disassembly Telomeric Loop Disassembly Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Spermidine Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Ectoderm Development Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Cell-cell Adhesion Involved In Gastrulation Glutamatergic Synapse
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