LDHA and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		LDHA	TINF2
Description		lactate dehydrogenase A	TERF1 interacting nuclear factor 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Exosome Oxidoreductase Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Cadherin Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Lactate Metabolic Process Glycolytic Process Glucose Catabolic Process To Lactate Via Pyruvate Carboxylic Acid Metabolic Process Substantia Nigra Development Pyruvate Catabolic Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Pyruvate metabolism Regulation of pyruvate metabolism	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		NADH Etheno-NAD Nicotinamide Oxamic Acid Stiripentol Copper Artenimol
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Amyloid A serum levels ( 21124955) Serum metabolite levels ( 33031748)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		21 interacting genes: ABCC9 ACD CEBPA DUX4 DYNLL1 FGFR1 GSK3A HNRNPD HULC KCNJ11 MAPK10 NDRG1 PCNA POT1 PTPRF SRPK2 TERF1 TINF2 UPF2 XRN1 YWHAQ	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		3939	26277
HPRD ID		01025	16056
Ensembl ID		ENSG00000134333	ENSG00000092330
Uniprot IDs		P00338 V9HWB9	B4DFJ1 Q9BSI4
PDB IDs		1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L 5ZJD 5ZJE 5ZJF 6BAD 6BAG 6BAX 6BAZ 6BB0 6BB1 6BB2 6BB3 6MV8 6MVA 6Q0D 6Q13 6SBU 6SBV 6ZZR 7M2N 8FW6 9BK2 9BK3	3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Capping Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Regulation Of Chromosome Organization Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Response To Metal Ion Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Protein-containing Complex Binding RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Macromolecule Metabolic Process Liver Development Inward Rectifying Potassium Channel Nucleobase-containing Compound Metabolic Process Regulation Of DNA Replication Regeneration ATP-activated Inward Rectifier Potassium Channel Activity Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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