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ACD and HSP90AB1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
ACD
HSP90AB1
Description
ACD shelterin complex subunit and telomerase recruitment factor
heat shock protein 90 alpha family class B member 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Telomerase Holoenzyme Complex
Nuclear Body
Shelterin Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
COP9 Signalosome
Cell Surface
Membrane
Protein-containing Complex
Aryl Hydrocarbon Receptor Complex
Secretory Granule Lumen
Melanosome
Neuronal Cell Body
Dendritic Growth Cone
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Protein Folding Chaperone Complex
Dynein Axonemal Particle
Ficolin-1-rich Granule Lumen
HSP90-CDC37 Chaperone Complex
Molecular Function
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
Telomeric DNA Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Nucleotide Binding
RNA Binding
Double-stranded RNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
ATP-dependent Protein Binding
Protein Folding Chaperone
Cadherin Binding
Protein Dimerization Activity
Tau Protein Binding
Unfolded Protein Binding
DNA Polymerase Binding
Protein Phosphatase Activator Activity
Disordered Domain Specific Binding
ATP-dependent Protein Folding Chaperone
Receptor Ligand Inhibitor Activity
Histone Methyltransferase Binding
Biological Process
Telomere Maintenance
Skeletal System Development
Urogenital System Development
Intracellular Protein Transport
Telomere Maintenance Via Telomerase
Telomere Capping
Embryonic Limb Morphogenesis
Protection From Non-homologous End Joining At Telomere
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Segmentation
Protein Localization To Chromosome, Telomeric Region
Establishment Of Protein Localization To Telomere
Regulation Of Establishment Of Protein Localization To Telomere
Placenta Development
Protein Folding
Response To Unfolded Protein
Telomere Maintenance Via Telomerase
Virion Attachment To Host Cell
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Apoptotic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Protein Stabilization
Chaperone-mediated Protein Complex Assembly
Regulation Of Cell Cycle
Cellular Response To Interleukin-4
Supramolecular Fiber Organization
Negative Regulation Of Proteasomal Protein Catabolic Process
Telomerase Holoenzyme Complex Assembly
Positive Regulation Of Protein Localization To Cell Surface
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of actin dynamics for phagocytic cup formation
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Sema3A PAK dependent Axon repulsion
Uptake and function of diphtheria toxin
Neutrophil degranulation
The NLRP3 inflammasome
The role of GTSE1 in G2/M progression after G2 checkpoint
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
RHOBTB2 GTPase cycle
Estrogen-dependent gene expression
Chaperone Mediated Autophagy
Purinergic signaling in leishmaniasis infection
Potential therapeutics for SARS
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Assembly and release of respiratory syncytial virus (RSV) virions
Respiratory syncytial virus genome replication
Drugs
Geldanamycin
9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
Radicicol
Tanespimycin
SNX-5422
CCT-018159
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE
(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE
METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Polaprezinc
Diseases
GWAS
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
64 interacting genes:
ACTB
ADPRH
AFAP1L2
AIPL1
ANKMY2
ANXA8L1
APOBEC3F
BAG3
CKB
CTTN
DBN1
DBNL
DCX
DPYSL3
EIF3G
EIF4B
ENO2
ENSA
FAM131B
FBXW7
FKBP6
GAPDH
HSP90AB1
IPO5
IVL
LASP1
LDHA
LGALSL
LLGL1
LRRC25
NCDN
NTAQ1
NUDC
NUDCD2
PAGE2
PDLIM2
PEX5
PFKP
PGM2
POT1
RBKS
RECQL4
RGS3
RPSA
SBDS
STIP1
STUB1
SULT1C2
TAGLN
TBC1D10A
TBCD
TINF2
TOMM34
TRIM15
TRIM16
TRIM55
TRIM63
TUBB2A
TUBB4B
USP7
XRCC6
YWHAE
ZFP36L1
ZNF790
68 interacting genes:
ACD
AKT1
ANXA1
ARHGAP1
BTG3
CCT2
CDC37L1
CDK4
CDKN2A
CHORDC1
CHUK
CLIC4
CSNK2A1
CYP17A1
DDX24
EGFR
ENO1
ERBB2
ESR1
ESRRB
FCHSD2
GSK3A
GSK3B
HSPB1
IKBKB
IKBKE
IKBKG
ITGB1BP2
KEAP1
MAP3K14
MAP3K3
MAPK6
MKNK1
MYCBP2
NR2C2
NR3C1
NR4A1
OGT
PGR
POT1
PPID
PTP4A2
RAF1
RHOBTB2
SERPINB5
SGTA
SHKBP1
SIRPA
SLC34A1
STARD13
STAT1
STAT3
SUMO2
TAF1D
TBK1
TERF1
TINF2
TNNT1
TP53
TSSK6
UBE2D3
UBE3A
UNC45A
USP50
WASL
WEE2-AS1
XIAP
YWHAB
Entrez ID
65057
3326
HPRD ID
12417
06763
Ensembl ID
ENSG00000102977
ENSG00000096384
Uniprot IDs
A0A8Q3WM11
Q96AP0
B4DGL0
P08238
Q6PK50
PDB IDs
2I46
5H65
5I2X
5I2Y
5UN7
5XYF
7QXA
7QXB
7QXS
7S1T
7TRE
8SOJ
8SOK
1QZ2
1UYM
2L6J
3FWV
3NMQ
3PRY
3UQ3
5FWK
5FWL
5FWM
5FWP
5UC4
5UCH
5UCI
5UCJ
6N8W
6N8Y
7ULJ
7Z37
7Z38
7ZR0
7ZR5
7ZR6
7ZUB
8EOA
8EOB
8GAE
8GFT
8QMO
Enriched GO Terms of Interacting Partners
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Cytoplasm
Cytosol
Cadherin Binding
Carbohydrate Catabolic Process
Nuclear Telomere Cap Complex
Protein Folding Chaperone Complex
Substantia Nigra Development
ADP Catabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Glycolytic Process
Telomere Maintenance
Cellular Response To Heat
ADP Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Nucleoside Diphosphate Catabolic Process
Monosaccharide Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
Unfolded Protein Binding
Telomeric D-loop Binding
Telomere Assembly
Organelle Organization
Neural Nucleus Development
Pyruvate Metabolic Process
Glucose Metabolic Process
Telomere Organization
Protein Folding
Cortical Cytoskeleton
Glucose Catabolic Process
Telomeric DNA Binding
Protein Binding
Shelterin Complex
Ribonucleoside Diphosphate Metabolic Process
Purine Ribonucleotide Catabolic Process
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Cytoskeleton Organization
Cytoskeleton
Microtubule Cytoskeleton Organization
Nucleoside Diphosphate Metabolic Process
Protein Stabilization
Chaperone-mediated Autophagy
Microtubule
Response To Heat
Purine Nucleotide Catabolic Process
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Hexose Metabolic Process
Microtubule Cytoskeleton
Intercellular Bridge
Telomeric D-loop Disassembly
Hsp90 Protein Binding
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Kinase Activity
Intracellular Signaling Cassette
Cytosol
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Intracellular Signal Transduction
Identical Protein Binding
Kinase Activity
Nuclear Receptor Activity
Negative Regulation Of Macromolecule Metabolic Process
Shelterin Complex
Protein Serine Kinase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Proteolysis
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Telomere Maintenance Via Telomerase
Nuclear Telomere Cap Complex
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
IkappaB Kinase Activity
Nucleus
Estrogen Response Element Binding
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
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Tagcloud (Intersection)
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