FTH1 and MYL3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FTH1	MYL3
Gene Name		ferritin, heavy polypeptide 1	myosin, light chain 3, alkali; ventricular, skeletal, slow
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Intracellular Ferritin Complex Extracellular Vesicular Exosome	Cytosol Muscle Myosin Complex Sarcomere A Band I Band
	Molecular Function	Ferroxidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding	Motor Activity Actin Monomer Binding Calcium Ion Binding Structural Constituent Of Muscle Myosin II Heavy Chain Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Immune Response Negative Regulation Of Cell Proliferation Negative Regulation Of Fibroblast Proliferation Transmembrane Transport Oxidation-reduction Process Membrane Organization	Regulation Of The Force Of Heart Contraction Regulation Of Striated Muscle Contraction Skeletal Muscle Tissue Development Metabolic Process Muscle Filament Sliding Positive Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Striated Muscle Contraction
Drugs		Iron Dextran
Diseases
GWAS		Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		31 interactors: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 PACSIN1 PIAS4 SDCBP SOX5 SPP1 TICAM2 TOLLIP TRAF4 UBR1 WDYHV1 YWHAE	3 interactors: ATG101 CASP3 FTH1
Entrez ID		2495	4634
HPRD ID		00615	01183
Ensembl ID		ENSG00000167996	ENSG00000160808
Uniprot IDs		P02794	P08590
PDB IDs		1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Metabolic Process Chemotaxis Positive Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Response To Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cell Communication Regulation Of Protein Metabolic Process System Development Movement Of Cell Or Subcellular Component Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Generation Of Neurons Anatomical Structure Development Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Toll-like Receptor Signaling Pathway Locomotion Positive Regulation Of Protein Sumoylation Signaling Response To Hormone Neurogenesis Cellular Response To Lipid Leukocyte Migration Signal Transduction Regulation Of Signaling Steroid Hormone Mediated Signaling Pathway Multicellular Organismal Development Regulation Of Protein Sumoylation Response To External Stimulus Leukocyte Chemotaxis Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of JNK Cascade Cell Migration Response To Lipid Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Transcription From RNA Polymerase II Promoter Cell Motility Negative Regulation Of Gene Expression	Intracellular Sequestering Of Iron Ion Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Sequestering Of Metal Ion Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of B Cell Proliferation Apoptotic DNA Fragmentation Negative Regulation Of Cell Proliferation Platelet Formation Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Release Of Cytochrome C From Mitochondria Apoptotic Nuclear Changes Negative Regulation Of Fibroblast Proliferation Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?		aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim	3p21 acylpeptide add apeh assign backcross band chromosomally chromosome chromosomes conservation dnas fourth hydrolase interspecific longest mapped myosin osteosarcoma p22 parathyroid pthr rpthrec4 segregated spanning synteny tf transferrin umr
Tagcloud (Difference) ?		aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim	3p21 acylpeptide add apeh assign backcross band chromosomally chromosome chromosomes conservation dnas fourth hydrolase interspecific longest mapped myosin osteosarcoma p22 parathyroid pthr rpthrec4 segregated spanning synteny tf transferrin umr
Tagcloud (Intersection) ?