FTH1 and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		FTH1	TOLLIP
Description		ferritin heavy chain 1	toll interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Lysosome Autophagosome Cytosol Cytoplasmic Vesicle Autolysosome Extracellular Exosome Ferritin Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Extrinsic Component Of Plasma Membrane Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Ferroxidase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Iron Ion Sequestering Activity	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding Molecular Adaptor Activity
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis Immune Response Negative Regulation Of Cell Population Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Ferroptosis	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	Neutrophil degranulation Interleukin-1 signaling
Drugs		Iron Dextran Iron Ferric pyrophosphate citrate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Estradiol levels ( 22675492) Major depressive disorder x sex interaction ( 34099189) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)	Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		42 interacting genes: BAG4 BRD7 CD99 CDC16 CDC25A CDC42 CRMP1 CSF3R CSNK2B DAXX DLG4 ELL3 FTL FXR1 FXR2 GOLM1 GPR35 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 NTAQ1 OPTN PACSIN1 PCBP1 PCBP2 PIAS4 SDCBP SIRPA SNCA SOX5 SPP1 STAT1 TICAM2 TOLLIP TRAF4 UBR1 YWHAE	78 interacting genes: ACTMAP ACTN2 ARRDC3 ATXN1 BHLHE40 CDIP1 CHD6 CIMIP2B CPSF6 CSN1S1 CSN2 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NEDD8 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF167 RNF26 RSPH1 RUNX1 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TTC9C USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19
Entrez ID		2495	54472
HPRD ID		00615	05887
Ensembl ID		ENSG00000167996	ENSG00000078902
Uniprot IDs		P02794	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0 4OYN 4Y08 4YKH 4ZJK 5CMQ 5CMR 5GN8 5GOU 5JKK 5JKL 5JKM 5N26 5N27 5UP7 5UP8 5UP9 5VTD 5XB1 5YI5 5ZND 6B8F 6B8G 6FTV 6GSR 6H5I 6H6T 6H6U 6IPC 6IPO 6IPP 6IPQ 6J4A 6J7G 6JOB 6JPS 6KE2 6KE4 6M52 6M54 6WYF 6WYG 6WYH 6Z6U 6Z9E 6Z9F 7A6A 7A6B 7CK8 7CK9 7JGK 7JGL 7JGM 7JGN 7JGO 7JGP 7JGQ 7K26 7K3V 7K3W 7KE3 7KE5 7PF1 7R5O 7RRP 7V66 7VD8 7ZG7 8A2L 8A2M 8A5N 8AAV 8B7O 8CPM 8CPS 8CPT 8CPU 8CPV 8CPW 8CPX 8DHX 8DNP 8F49 8F4L 8HHS 8J9L 8J9M 8JAI 8KFD 8PP2 8PP3 8PP5 8QU9 8W92 8WB3 8WIE 8WIQ 8WJF 8XWB 8Y6F 9JIU 9JQB 9JQC 9JQD 9JQE 9KAY	1WGL 2N31
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Cytosol Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Communication Negative Regulation Of Transport Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Cell Communication Intracellular Receptor Signaling Pathway Postsynapse Negative Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Localization Within Membrane Cytoplasmic Ribonucleoprotein Granule Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signaling Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Protein Phosphatase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Type II Interferon Regulation Of Endocytosis Phosphoprotein Binding Viral RNA Genome Replication Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Kinase Binding Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Dendrite Positive Regulation Of Biosynthetic Process Protein Sequestering Activity Protein-macromolecule Adaptor Activity Neuron Projection Lipid Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Adhesion Regulation Of Primary Metabolic Process	NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-1-mediated Signaling Pathway Endosome Membrane Ubiquitin Binding Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Golgi To Plasma Membrane Protein Transport Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Protein Binding Toll-like Receptor Signaling Pathway Intermediate Filament Cell Surface Pattern Recognition Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Phosphatidylinositol Binding Golgi To Plasma Membrane Transport Interleukin-1 Receptor Activity Toll-like Receptor 2 Signaling Pathway Embryonic Hindlimb Morphogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface LIM Domain Binding Toll Signaling Pathway Lipopolysaccharide Immune Receptor Activity Interleukin-33-mediated Signaling Pathway Hindlimb Morphogenesis Forelimb Morphogenesis Identical Protein Binding
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