KIF5B and NDRG1

Number of citations: 0 (PubMedID 17220478)
Data Source: HPRD (in vivo)

		KIF5B	NDRG1
Name		kinesin family member 5B	N-myc downstream regulated 1
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Endocytic Vesicle Nuclear Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Cytolytic Granule Membrane Axon Cytoplasm	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Identical Protein Binding Protein-containing Complex Binding Cadherin Binding	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Microtubule-based Movement Cytoplasm Organization Axon Guidance Positive Regulation Of Synaptic Transmission, GABAergic Lysosome Localization Stress Granule Disassembly Natural Killer Cell Mediated Cytotoxicity Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Mitochondrion Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Type II Interferon Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Anterograde Axonal Protein Transport Mitocytosis Positive Regulation Of Protein Localization To Plasma Membrane Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Anti-saccade response ( 29064472 ) Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Glycine levels ( 30837465 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Estimated glomerular filtration rate ( 31015462 ) Left-handedness ( 32989287 ) Nontyphoidal Salmonella bacteraemia ( 29523850 ) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511 )
Interacting Genes		37 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 CEBPA DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SCGN SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAQ YWHAZ ZBTB8A	71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		3799	10397
HPRD ID		07214	05586
Ensembl ID		ENSG00000170759	ENSG00000104419
Uniprot IDs		P33176 Q6P164 V9HW29	Q8N959 Q92597
PDB IDs		1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ 7RIK 8IXA 8IXB 8IXD 8IXE 8IXF 8IXG 8RHB 8RHH 8RIK 8RIZ 9GNQ	6ZMM
GO Terms Enriched among Interactors		Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Postsynapse Secretory Granule Localization CAMP Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Localization To Centrosome Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Intracellular Protein Localization Neuron Projection Establishment Of Vesicle Localization Vesicle CAMP-dependent Protein Kinase Regulator Activity Protein Targeting Phosphoserine Residue Binding Kinesin Binding Protein Sequestering Activity Perinuclear Region Of Cytoplasm Cytoplasm Negative Regulation Of Protein Localization To Nucleus Presynapse Ciliary Rootlet Vesicle Localization Dense Core Granule Cytoskeletal Transport Hippocampal Mossy Fiber To CA3 Synapse Positive Regulation Of Protein Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Cytoskeletal Trafficking Vesicle Fusion To Plasma Membrane Beta-catenin Destruction Complex Regulation Of Protein Localization To Centrosome Focal Adhesion Establishment Of Organelle Localization Intracellular Signal Transduction Establishment Of Protein Localization Wnt Signalosome Negative Regulation Of Calcineurin-NFAT Signaling Cascade Synaptic Vesicle Membrane Organization Cadherin Binding Synaptic Vesicle Priming Regulation Of Protein Localization Negative Regulation Of Signal Transduction Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Synapse TOR Signaling	Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression