KIF5B and PRKAR2B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KIF5B	PRKAR2B
Gene Name		kinesin family member 5B	protein kinase, cAMP-dependent, regulatory, type II, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Kinesin Complex Microtubule Membrane Endocytic Vesicle Vesicle Ciliary Rootlet Neuron Projection Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Ciliary Base
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity	CAMP-dependent Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Microtubule-based Movement Cytoplasm Organization Axon Guidance Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Cellular Protein Metabolic Process Vesicle Transport Along Microtubule Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Renal Water Homeostasis Energy Reserve Metabolic Process Fatty Acid Metabolic Process Water Transport Organelle Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Learning Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Ca-dependent events Signaling by GPCR CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling DAP12 signaling Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Mitotic G2-G2/M phases Organelle biogenesis and maintenance G2/M Transition DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Loss of Nlp from mitotic centrosomes DARPP-32 events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Assembly of the primary cilium G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog PLC-gamma1 signalling Centrosome maturation
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984)	Adverse response to lamotrigine and phenytoin ( 22379998) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		23 interactors: APC CDC5L DTNB GSK3B KIF5A KLC3 KTN1 NCOA2 NDRG1 PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A	14 interactors: AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 GNAI3 KIF5B LASP1 MAATS1 NBEA TAF12
Entrez ID		3799	5577
HPRD ID		07214	01486
Ensembl ID		ENSG00000170759	ENSG00000005249
Uniprot IDs		P33176 Q6P164	B3KY43 P31323
PDB IDs		1BG2 1MKJ 2P4N 4HNA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Protein Transport Establishment Of Protein Localization Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Development Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Apoptotic Process Mast Cell Activation Programmed Cell Death Regulation Of Intracellular Transport Intracellular Signal Transduction Cell Death Cellular Localization Death Regulation Of Apoptotic Process Intracellular Transport Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Transmission Neurogenesis Positive Regulation Of Signal Transduction Histamine Secretion By Mast Cell Signaling Regulation Of Organelle Organization Nervous System Development Cell Communication Transport Regulation Of Cellular Component Organization Synaptic Vesicle Priming Histamine Secretion	Regulation Of Protein Kinase A Signaling Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Membrane Potential Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Regulation Of CAMP Biosynthetic Process Stress Granule Disassembly Regulation Of CAMP Metabolic Process Blood Coagulation Hemostasis Response To CAMP Positive Regulation Of Delayed Rectifier Potassium Channel Activity Protein Localization Positive Regulation Of Protein Kinase A Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Organophosphorus Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Body Fluid Levels Regulation Of Signaling Synaptic Transmission Wound Healing Response To Purine-containing Compound Cytoplasm Organization Regulation Of Ion Transport Regulation Of Delayed Rectifier Potassium Channel Activity Response To Wounding Positive Regulation Of Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sexual Reproduction Positive Regulation Of Synaptic Transmission, GABAergic Transport
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?