KIF5B and POLR2G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIF5B	POLR2G
Description		kinesin family member 5B	RNA polymerase II subunit G
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Endocytic Vesicle Nuclear Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Cytolytic Granule Membrane Axon Cytoplasm	DNA-directed RNA Polymerase Complex P-body Nucleus Nucleoplasm RNA Polymerase II, Core Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Identical Protein Binding Protein-containing Complex Binding Cadherin Binding	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Translation Initiation Factor Binding
	Biological Process	Microtubule-based Movement Cytoplasm Organization Axon Guidance Positive Regulation Of Synaptic Transmission, GABAergic Lysosome Localization Stress Granule Disassembly Natural Killer Cell Mediated Cytotoxicity Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Mitochondrion Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Type II Interferon Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Anterograde Axonal Protein Transport Mitocytosis Positive Regulation Of Protein Localization To Plasma Membrane Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport	Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Bipolar disorder with mood-incongruent psychosis ( 23092984) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycine levels ( 30837465) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 CEBPA DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SCGN SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAQ YWHAZ ZBTB8A	45 interacting genes: ATF7IP BCL2L15 C22orf15 CIB3 CNTNAP2 DDX54 DES DUSP29 EIF3D EIF4A3 EWSR1 FNDC4 FOSL2 GPKOW HOXC5 KIF5B LMO2 MAPK1 MCM3AP MCPH1 MYOD1 NOTCH2NLA NTRK2 OSGIN1 PARVG POLR1C POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H PRKRA PSMB8 RPAP1 TAF15 TNNC1 TRAPPC2L TRIM14 TRIM68 TSEN15 UPRT VHL WHR1 ZNF410
Entrez ID		3799	5436
HPRD ID		07214	15995
Ensembl ID		ENSG00000170759	ENSG00000168002
Uniprot IDs		P33176 Q6P164 V9HW29	P62487
PDB IDs		1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ 7RIK 8IXA 8IXB 8IXD 8IXE 8IXF 8IXG 8RHB 8RHH 8RIK 8RIZ 9GNQ	2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Postsynapse Secretory Granule Localization CAMP Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Localization To Centrosome Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Intracellular Protein Localization Neuron Projection Establishment Of Vesicle Localization Vesicle CAMP-dependent Protein Kinase Regulator Activity Protein Targeting Phosphoserine Residue Binding Kinesin Binding Protein Sequestering Activity Perinuclear Region Of Cytoplasm Cytoplasm Negative Regulation Of Protein Localization To Nucleus Presynapse Ciliary Rootlet Vesicle Localization Dense Core Granule Cytoskeletal Transport Hippocampal Mossy Fiber To CA3 Synapse Positive Regulation Of Protein Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Cytoskeletal Trafficking Vesicle Fusion To Plasma Membrane Beta-catenin Destruction Complex Regulation Of Protein Localization To Centrosome Focal Adhesion Establishment Of Organelle Localization Intracellular Signal Transduction Establishment Of Protein Localization Wnt Signalosome Negative Regulation Of Calcineurin-NFAT Signaling Cascade Synaptic Vesicle Membrane Organization Cadherin Binding Synaptic Vesicle Priming Regulation Of Protein Localization Negative Regulation Of Signal Transduction Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Synapse TOR Signaling	DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleoplasm Transcription By RNA Polymerase II DNA-templated Transcription Nucleus Cerebral Cortex Development Nucleolus RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus Outer Ear Morphogenesis Macromolecule Biosynthetic Process Transcription Coregulator Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Contractile Muscle Fiber Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Striatum Development Transcription By RNA Polymerase I DNA Binding
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