KIF5B and KIF5A

Number of citations of the paper that reports this interaction (PubMedID 38334954)
77

Data Source:
BioGRID (cross-linking study, cross-linking study)
HPRD (in vivo)

		KIF5B	KIF5A
Description		kinesin family member 5B	kinesin family member 5A
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Endocytic Vesicle Nuclear Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Cytolytic Granule Membrane Axon Cytoplasm	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Ciliary Rootlet Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Axon Cytoplasm
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Identical Protein Binding Protein-containing Complex Binding Cadherin Binding	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding
	Biological Process	Microtubule-based Movement Cytoplasm Organization Axon Guidance Positive Regulation Of Synaptic Transmission, GABAergic Lysosome Localization Stress Granule Disassembly Natural Killer Cell Mediated Cytotoxicity Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Mitochondrion Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Type II Interferon Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Anterograde Axonal Protein Transport Mitocytosis Positive Regulation Of Protein Localization To Plasma Membrane Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport	Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Anti-saccade response ( 29064472) Bipolar disorder with mood-incongruent psychosis ( 23092984) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycine levels ( 30837465) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 18794853 24449572) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		37 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 CEBPA DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SCGN SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAQ YWHAZ ZBTB8A	24 interacting genes: BACH1 CREBBP DSCAM DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 MAPK10 NCOA2 NDEL1 NRIP1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSC1 TSG101 YAP1
Entrez ID		3799	3798
HPRD ID		07214	09108
Ensembl ID		ENSG00000170759	ENSG00000155980
Uniprot IDs		P33176 Q6P164 V9HW29	J3KNA1 Q12840
PDB IDs		1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ 7RIK 8IXA 8IXB 8IXD 8IXE 8IXF 8IXG 8RHB 8RHH 8RIK 8RIZ 9GNQ	4UXT 4UXY 4UY0
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Postsynapse Secretory Granule Localization CAMP Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Localization To Centrosome Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Intracellular Protein Localization Neuron Projection Establishment Of Vesicle Localization Vesicle CAMP-dependent Protein Kinase Regulator Activity Protein Targeting Phosphoserine Residue Binding Kinesin Binding Protein Sequestering Activity Perinuclear Region Of Cytoplasm Cytoplasm Negative Regulation Of Protein Localization To Nucleus Presynapse Ciliary Rootlet Vesicle Localization Dense Core Granule Cytoskeletal Transport Hippocampal Mossy Fiber To CA3 Synapse Positive Regulation Of Protein Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Cytoskeletal Trafficking Vesicle Fusion To Plasma Membrane Beta-catenin Destruction Complex Regulation Of Protein Localization To Centrosome Focal Adhesion Establishment Of Organelle Localization Intracellular Signal Transduction Establishment Of Protein Localization Wnt Signalosome Negative Regulation Of Calcineurin-NFAT Signaling Cascade Synaptic Vesicle Membrane Organization Cadherin Binding Synaptic Vesicle Priming Regulation Of Protein Localization Negative Regulation Of Signal Transduction Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Synapse TOR Signaling	Cytoplasm Ciliary Rootlet Kinesin Complex Microtubule Neuron Projection Axo-dendritic Transport Postsynaptic Cytosol Intracellular Signal Transduction Establishment Of Vesicle Localization Microtubule Binding Vesicle Localization Transcription Coregulator Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Axon Cytoplasm Transport Along Microtubule Axonal Transport Anterograde Dendritic Transport Protein Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Transcription Corepressor Activity Microtubule-based Transport Dendritic Transport Positive Regulation Of GTPase Activity Proline-rich Region Binding Plus-end-directed Microtubule Motor Activity Regulation Of Modification Of Synaptic Structure Retrograde Axonal Transport Positive Regulation Of Cell Communication Rhythmic Process Positive Regulation Of Signaling Signal Transduction Establishment Of Organelle Localization Positive Regulation Of Hydrolase Activity Cell Projection Organization Transcription Coactivator Activity Dendrite Cytoplasm Positive Regulation Of Cellular Component Biogenesis Hippo Signaling Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Nervous System Development Centrosome Localization Regulation Of GTPase Activity Response To Progesterone Regulation Of Cellular Component Organization Synaptic Vesicle Transport Regulation Of Protein Localization
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