NHLRC1 and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 15930137)
55

Data Source:
BioGRID (pull down)

		NHLRC1	UBE2H
Description		NHL repeat containing E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 H
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Glycogen Metabolic Process Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Intrinsic epigenetic age acceleration ( 29374233)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: AGL GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		378884	7328
HPRD ID		06995	03052
Ensembl ID		ENSG00000187566	ENSG00000186591
Uniprot IDs		Q6VVB1	A0A3B3IU20 A4D1L5 P62256
PDB IDs			2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Protein K48-linked Ubiquitination Glycogen Metabolic Process Ubiquitin-protein Transferase Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Polyubiquitination Carbohydrate Biosynthetic Process Transferase Activity Inclusion Body Macromolecule Catabolic Process Macromolecule Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Generation Of Precursor Metabolites And Energy Protein Modification Process Post-translational Protein Modification Negative Regulation Of BMP Signaling Pathway Isoamylase Complex 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Carbohydrate Metabolic Process Catabolic Process Glycogen Synthase Activity, Transferring Glucose-1-phosphate Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Proteolysis Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Protein Lipoylation ISG15 Transferase Activity Protein Catabolic Process ATP Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Glycosyltransferase Activity Glycogen Binding D-glucose Binding Protein Metabolic Process Nucleotide Binding	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
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