NHLRC1

Description		NHL repeat containing E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Glycogen Metabolic Process Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		8 interacting genes: AGL GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H
Entrez ID		378884
HPRD ID		06995
Ensembl ID		ENSG00000187566
Uniprot IDs		Q6VVB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Protein K48-linked Ubiquitination Glycogen Metabolic Process Ubiquitin-protein Transferase Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Polyubiquitination Carbohydrate Biosynthetic Process Transferase Activity Inclusion Body Macromolecule Catabolic Process Macromolecule Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Generation Of Precursor Metabolites And Energy Protein Modification Process Post-translational Protein Modification Negative Regulation Of BMP Signaling Pathway Isoamylase Complex 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Carbohydrate Metabolic Process Catabolic Process Glycogen Synthase Activity, Transferring Glucose-1-phosphate Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Proteolysis Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Protein Lipoylation ISG15 Transferase Activity Protein Catabolic Process ATP Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Glycosyltransferase Activity Glycogen Binding D-glucose Binding Protein Metabolic Process Nucleotide Binding
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