NHLRC1 and NNAT

Number of citations of the paper that reports this interaction (PMID 21742036)
6

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NHLRC1	NNAT
Gene Name		NHL repeat containing E3 ubiquitin protein ligase 1	neuronatin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Protein Polyubiquitination Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Autophagy Pathogenesis Positive Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Small Molecule Metabolic Process	Transport Brain Development Protein Lipoylation Neuron Differentiation
Pathways		Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AGL EPM2A NNAT PPP1R3C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H	2 interactors: APP NHLRC1
Entrez ID		378884	4826
HPRD ID		06995	04377
Ensembl ID		ENSG00000187566	ENSG00000053438
Uniprot IDs		Q6VVB1	Q16517
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Glycogen Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Catabolic Process Polysaccharide Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Glycogen Metabolic Process Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Macromolecule Catabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Energy Reserve Metabolic Process Activation Of Innate Immune Response Glucose Metabolic Process Carbohydrate Biosynthetic Process Cellular Protein Modification Process Protein K11-linked Ubiquitination Positive Regulation Of Innate Immune Response Pathogenesis Hexose Metabolic Process Cellular Carbohydrate Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Innate Immune Response Monosaccharide Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Checkpoint Proteasomal Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Proteolysis Spindle Checkpoint	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Glycogen Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Glycogen Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Polysaccharide Metabolic Process Regulation Of Cellular Protein Metabolic Process Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity
Tagcloud ?		accepted apparently asses ataxia autosomal bodies cerebral characterizing codifying cortex dysregulation epm2a epm2b gabaergic glycogen imply lafora laforin malin myoclonic myoclonus neurodegeneration neurodevelopment neurotrophins operate p75ntr recessive seizures want	alleles androgenetic chimeras eg embryos endure epigenotype es exceptions gametic germ h19 heritable igf2 imprinted imprints mest overgrowth p57kip2 parthenogenetic paternal pefs peg1 peg3 pgcs primordial resemble strikingly unmethylated
Tagcloud (Difference) ?		accepted apparently asses ataxia autosomal bodies cerebral characterizing codifying cortex dysregulation epm2a epm2b gabaergic glycogen imply lafora laforin malin myoclonic myoclonus neurodegeneration neurodevelopment neurotrophins operate p75ntr recessive seizures want	alleles androgenetic chimeras eg embryos endure epigenotype es exceptions gametic germ h19 heritable igf2 imprinted imprints mest overgrowth p57kip2 parthenogenetic paternal pefs peg1 peg3 pgcs primordial resemble strikingly unmethylated
Tagcloud (Intersection) ?