NHLRC1 and NNAT

Number of citations of the paper that reports this interaction (PubMedID 21742036)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NHLRC1	NNAT
Description		NHL repeat containing E3 ubiquitin protein ligase 1	neuronatin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Glycogen Metabolic Process Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane	Brain Development Protein Lipoylation Positive Regulation Of Insulin Secretion
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		8 interacting genes: AGL GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H	2 interacting genes: APP NHLRC1
Entrez ID		378884	4826
HPRD ID		06995	04377
Ensembl ID		ENSG00000187566	ENSG00000053438
Uniprot IDs		Q6VVB1	A0A3B3ITN5 Q16517
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Protein K48-linked Ubiquitination Glycogen Metabolic Process Ubiquitin-protein Transferase Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Polyubiquitination Carbohydrate Biosynthetic Process Transferase Activity Inclusion Body Macromolecule Catabolic Process Macromolecule Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Generation Of Precursor Metabolites And Energy Protein Modification Process Post-translational Protein Modification Negative Regulation Of BMP Signaling Pathway Isoamylase Complex 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Carbohydrate Metabolic Process Catabolic Process Glycogen Synthase Activity, Transferring Glucose-1-phosphate Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Proteolysis Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Protein Lipoylation ISG15 Transferase Activity Protein Catabolic Process ATP Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Glycosyltransferase Activity Glycogen Binding D-glucose Binding Protein Metabolic Process Nucleotide Binding	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Humoral Immune Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Defense Response To Bacterium Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Response To Bacterium Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding
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