NHLRC1 and PPP1R3C

Number of citations of the paper that reports this interaction (PMID 18070875)
37

Data Source:
BioGRID (enzymatic study, two hybrid)

		NHLRC1	PPP1R3C
Gene Name		NHL repeat containing E3 ubiquitin protein ligase 1	protein phosphatase 1, regulatory subunit 3C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Binding
	Biological Process	Protein Polyubiquitination Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Autophagy Pathogenesis Positive Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Small Molecule Metabolic Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Pathogenesis Dephosphorylation Small Molecule Metabolic Process
Pathways		Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AGL EPM2A NNAT PPP1R3C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H	6 interactors: APP NHLRC1 PPP1CA PPP1CB PPP1CC SGTA
Entrez ID		378884	5507
HPRD ID		06995	04298
Ensembl ID		ENSG00000187566	ENSG00000119938
Uniprot IDs		Q6VVB1	Q9UQK1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Glycogen Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Catabolic Process Polysaccharide Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Glycogen Metabolic Process Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Macromolecule Catabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Energy Reserve Metabolic Process Activation Of Innate Immune Response Glucose Metabolic Process Carbohydrate Biosynthetic Process Cellular Protein Modification Process Protein K11-linked Ubiquitination Positive Regulation Of Innate Immune Response Pathogenesis Hexose Metabolic Process Cellular Carbohydrate Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Innate Immune Response Monosaccharide Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Checkpoint Proteasomal Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Proteolysis Spindle Checkpoint	Glycogen Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Photoperiodism Entrainment Of Circadian Clock Energy Reserve Metabolic Process Acylglycerol Catabolic Process Cellular Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Light Stimulus Circadian Regulation Of Gene Expression Regulation Of Glycogen Catabolic Process Regulation Of Circadian Rhythm Triglyceride Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Radiation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lipid Catabolic Process Regulation Of Glycogen Biosynthetic Process Protein Dephosphorylation Regulation Of Glycogen Metabolic Process Rhythmic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Response To Abiotic Stimulus Glycerolipid Metabolic Process Cell Division Lipid Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Dephosphorylation Oxidation-reduction Process Cellular Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Glucose Metabolic Process Response To Growth Factor Catabolic Process Response To External Stimulus Synaptic Growth At Neuromuscular Junction
Tagcloud ?		accepted apparently asses ataxia autosomal bodies cerebral characterizing codifying cortex dysregulation epm2a epm2b gabaergic glycogen imply lafora laforin malin myoclonic myoclonus neurodegeneration neurodevelopment neurotrophins operate p75ntr recessive seizures want	5p algorithm algorithms arrdc3 created false hippocampus integrating joint littermate lm mir139 mir3470a mirna mirnas modules mt networks omics pagerank predict prediction predictions sfpq tendency tg6799 topology transcriptome validation
Tagcloud (Difference) ?		accepted apparently asses ataxia autosomal bodies cerebral characterizing codifying cortex dysregulation epm2a epm2b gabaergic glycogen imply lafora laforin malin myoclonic myoclonus neurodegeneration neurodevelopment neurotrophins operate p75ntr recessive seizures want	5p algorithm algorithms arrdc3 created false hippocampus integrating joint littermate lm mir139 mir3470a mirna mirnas modules mt networks omics pagerank predict prediction predictions sfpq tendency tg6799 topology transcriptome validation
Tagcloud (Intersection) ?