KCNJ2 and DLG3

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		KCNJ2	DLG3
Gene Name		potassium channel, inwardly rectifying subfamily J, member 2	discs, large homolog 3 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)
Protein-Protein Interactions		14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2	40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1
Entrez ID		3759	1741
HPRD ID		02815	02177
Ensembl ID		ENSG00000123700	ENSG00000082458
Uniprot IDs		P63252	Q59FY1 Q92796
PDB IDs			1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport	Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization
Tagcloud ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus	17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus	17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?