KCNJ2 and TRAK2

Number of citations of the paper that reports this interaction (PMID 16895905)
8

Data Source:
HPRD (in vivo, two hybrid)

		KCNJ2	TRAK2
Gene Name		potassium channel, inwardly rectifying subfamily J, member 2	trafficking protein, kinesin binding 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Nucleus Cytoplasm Mitochondrion Early Endosome Plasma Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Receptor Binding Protein Binding Enzyme Binding GABA Receptor Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Transcription From RNA Polymerase II Promoter Protein O-linked Glycosylation Protein Targeting
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)
Protein-Protein Interactions		14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2	3 interactors: GABRB2 KCNJ2 OGT
Entrez ID		3759	66008
HPRD ID		02815	09547
Ensembl ID		ENSG00000123700	ENSG00000115993
Uniprot IDs		P63252	O60296
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport	Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Relaxation Of Skeletal Muscle Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Resting Membrane Potential Cellular Potassium Ion Homeostasis Positive Regulation Of Granulocyte Differentiation Cellular Response To Histamine Regulation Of Skeletal Muscle Contraction Synaptic Transmission, GABAergic Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Positive Regulation Of Histone H3-K27 Methylation Response To Histamine Cellular Chemical Homeostasis Histone H3-K4 Trimethylation Membrane Depolarization During Cardiac Muscle Cell Action Potential Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Repolarization Relaxation Of Cardiac Muscle Regulation Of Histone H3-K27 Methylation Potassium Ion Homeostasis Synaptic Transmission Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Homeostasis Cellular Response To Ammonium Ion Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Histone H3-K4 Methylation Potassium Ion Import Magnesium Ion Transport Regulation Of Glycolytic Process Peptidyl-lysine Trimethylation Cardiac Muscle Cell Action Potential Involved In Contraction Response To Organonitrogen Compound Positive Regulation Of Potassium Ion Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Homeostasis Histone H3-K4 Methylation Cell-cell Signaling Membrane Depolarization During Action Potential Innervation Regulation Of Rac Protein Signal Transduction Cardiac Muscle Cell Action Potential Positive Regulation Of Histone Methylation Regulation Of Potassium Ion Transmembrane Transport Inner Ear Receptor Cell Development
Tagcloud ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus	ancestor armc10 armcx armcx1 cluster comparisons conservation dynamics enhancers eutherian evolved fission kif5 localise localises mammals miro1 mitochondria mitochondrial moving neuroprotective neurotransmission organisation prevents retrotransposition syntenic trafficking underscore vertebrates
Tagcloud (Difference) ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus	ancestor armc10 armcx armcx1 cluster comparisons conservation dynamics enhancers eutherian evolved fission kif5 localise localises mammals miro1 mitochondria mitochondrial moving neuroprotective neurotransmission organisation prevents retrotransposition syntenic trafficking underscore vertebrates
Tagcloud (Intersection) ?