KCNJ2

Name	potassium inwardly rectifying channel subfamily J member 2
Structure
Novel Interactors	1 novel interactors: UTP18
Interactors	20 interactors: AKAP5 ARL13B CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 KCNJ11 KCNJ15 KCNJ16 KCNJ18 KCNJ4 KCNJ8 PATJ SDC3 SDCBP SEC22A TRAK2
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc Membrane T-tubule Dendrite Monoatomic Ion Channel Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Sensory perception of sour taste Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs	Ranolazine Miconazole Carvedilol Dronedarone
Diseases	Short QT syndrome Andersen-Tawil syndrome (ATS) Atrial fibrillation Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS	Adolescent idiopathic scoliosis (severe) ( 24023777 ) Alanine aminotransferase levels ( 33547301 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Atrial fibrillation ( 29892015 ) Birth weight ( 31043758 ) Chin dimples ( 27182965 ) Dentures ( 31235808 ) Depressive episodes in bipolar disorder ( 26297903 ) Early cardiac repolarization ( 22342860 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Formal thought disorder in schizophrenia ( 22648509 ) HDL cholesterol levels ( 32109663 32203549 ) Hip circumference adjusted for BMI ( 25673412 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Lung function (forced vital capacity) ( 24929828 ) Macular thickness ( 30535121 ) Metabolite levels ( 23823483 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Obesity-related traits ( 23251661 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 20195514 23704328 ) Prudent dietary pattern ( 28644415 ) Pulmonary function (smoking interaction) ( 23284291 ) QT interval ( 19305409 29874175 30679814 24952745 ) Refractive error ( 23396134 ) Renal overload gout ( 32238385 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142 ) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781 ) Thyrotoxic periodic paralysis ( 33105104 ) TPE interval (response to exercise) ( 32386560 ) TPE interval (resting) ( 32386560 ) Triglyceride levels ( 32203549 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )
Entrez ID	3759
HPRD ID	02815
Ensembl ID	ENSG00000123700
Uniprot IDs	P63252
PDB IDs	6SPZ 7ZDZ 8QQL
GO Terms Enriched among Interactors ?	Inward Rectifier Potassium Channel Activity Regulation Of Monoatomic Ion Transport Potassium Ion Import Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Plasma Membrane Inorganic Cation Import Across Plasma Membrane Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Establishment Or Maintenance Of Cell Polarity Voltage-gated Potassium Channel Complex Potassium Ion Transport Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Kinase Binding GMP Kinase Activity GDP Metabolic Process Metal Ion Transport Receptor Localization To Synapse Basolateral Plasma Membrane Protein Localization To Synapse Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Monoatomic Cation Transport Localization Within Membrane Trans-synaptic Signaling Neuromuscular Junction Adherens Junction Synaptic Signaling GMP Metabolic Process Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transport Postsynaptic Density Membrane Formation Of Radial Glial Scaffolds Inward Rectifying Potassium Channel Response To Resveratrol Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Cellular Localization Regulation Of Metal Ion Transport Cell-cell Signaling Response To Stilbenoid